Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice [PDF]
, 2016 Diabetic patients suffer from a high rate of cardiovascular events and such risk increases with HbA1c. However, lowering HbA1c does not appear to yield the same benefit on macrovascular endpoints, as observed for microvascular endpoints. As the number of
Avogaro, Angelo +4 more
core +3 more sources
Cell death in the cardiovascular system [PDF]
Heart, 2006 Cell death is important for both development and tissue homeostasis in the adult. As such, it is tightly controlled and deregulation is associated with diverse pathologies; for example, regulated cell death is involved in vessel remodelling during development or following injury, but deregulated death is implicated in pathologies such as ...
Murray, Clarke +2 more
openaire +2 more sources
Entosis: The emerging face of non-cell-autonomous type IV programmed death
Biomedical Journal, 2017 The present review summarizes recent experimental evidences about the existence of the non-cell-autonomous death entosis in physiological and pathophysiological contexts, discusses some aspects of this form of cell death, including morphological ...
Isabelle Martins +10 more
doaj +1 more source
Coronary-artery bypass surgery in patients with ischemic cardiomyopathy [PDF]
, 2016 BACKGROUND The survival benefit of a strategy of coronary-artery bypass grafting (CABG) added to guideline-directed medical therapy, as compared with medical therapy alone, in patients with coronary artery disease, heart failure, and severe left ...
Cox DR +19 more
core +1 more source
High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]
, 2014 Aims: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
A. L. Hunter +23 more
core +5 more sources
Sex differences in lifetime risk and first manifestation of cardiovascular disease: Prospective population based cohort study [PDF]
, 2014 Objective: To evaluate differences in first manifestations of cardiovascular disease between men and women in a competing risks framework. Design: Prospective population based cohort study.
Deckers, J.W. (Jaap) +14 more
core +4 more sources
Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]
, 2016 Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian +11 more
core +2 more sources
Migraine, headache, and mortality in women: a cohort study [PDF]
, 2020 Background: Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased risk of cardiovascular mortality.
Buring, Julie Elizabeth +3 more
core +1 more source
Cell Death in Cardiovascular Disease [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2011 Cell death has been recognized in the cardiovascular system for centuries. In Virchow's 1858 lectures, he described atherosclerosis as producing new tissue, followed by cell death: “Thus, we have here an active process which really produces new tissues, but then hurries on to destruction in consequence of its own development.”1 Degraded and dying cells
openaire +2 more sources
Physical activity and cardiovascular mortality risk: possible protective mechanisms? [PDF]
, 2012 INTRODUCTION: The biological mechanisms through which increased physical activity or structured exercise training lowers the risk of recurrent cardiac events are incompletely understood.
Apullan +25 more
core +2 more sources