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Are Energy Metabolism Alterations Involved in Cardiovascular Deconditioning After Weightlessness? An Hypothesis

Pflugers Archiv European Journal of Physiology, 2000
The physiopathogenesis of the cardiovascular deconditioning syndrome observed after actual and simulated microgravity is still under debate, despite numerous studies conducted on the role of blood volume, hormones involved in its regulation, sympathetic nervous system, baroreflexes and venous compliance.
Stéphane Blanc, Claude Gharib, L Somody
exaly   +3 more sources

Proposed role of the paraventricular nucleus in cardiovascular deconditioning

Acta Physiologica Scandinavica, 2002
AbstractAim: Cardiovascular deconditioning occurs in individuals exposed to prolonged spaceflight or bedrest and is associated with the development of orthostatic intolerance. Although the precise mechanisms remain to be fully elucidated, astronauts returning from space or bedrest patients returning to normal upright posture present with decreases in ...
P J, Mueller   +3 more
openaire   +2 more sources

Cardiovascular Deconditioning: From Autonomic Nervous System to Microvascular Dysfunctions

Respiratory Physiology and Neurobiology, 2009
Weightlessness induces an acute syndrome called the cardiovascular deconditioning, associating orthostatic intolerance with syncope, increase in resting heart rate and decrease in physical capability. Orthostatic intolerance occurs after short term and long term head down bed rest and after long term space flight.
Jacques-Olivier Fortrat   +2 more
exaly   +3 more sources

Central hypervolemia in the conscious rat: a model of cardiovascular deconditioning

Journal of Applied Physiology, 1996
The aim of the present study as to investigate whether increased central hypervolemia induced by tail suspension (TS) in the rat is an appropriate model of cardiovascular deconditioning (CVD). First, the physiological relationship between central venous pressure (CVP) and extracellular fluid volume (ECFV) was studied.
E, Martel   +5 more
openaire   +2 more sources

The cardiovascular effects of deconditioning after endurance training in rats

Acta Physiologica Scandinavica, 1988
The haemodynamic effects of endurance training and physical deconditioning were studied in anaesthetized rats using aortic and left ventricular pressure recordings and volume measurements by thermodilution method during isoproterenol and CaCl2 loads.
M K, Karhunen   +3 more
openaire   +2 more sources

Mechanisms of the cardiovascular deconditioning induced by tail suspension in the rat

American Journal of Physiology-Heart and Circulatory Physiology, 1998
The aim of the present work was to obtain insights into the pathophysiology of cardiovascular deconditioning (CVD) induced by tail suspension (TS) in the rat: during TS, when central venous pressure (CVP) has been normalized (E. Martel, P. Champéroux, P. Lacolley, S. Richard, M. Safar, and J. L. Cuche. J. Appl. Physiol.
E, Martel   +9 more
openaire   +2 more sources

Regulation of Sympathetic Nervous System Function after Cardiovascular Deconditioning

Annals of the New York Academy of Sciences, 2001
Abstract:Humans subjected to prolonged periods of bed rest or microgravity undergo deconditioning of the cardiovascular system, characterized by resting tachycardia, reduced exercise capability, and a predisposition for orthostatic intolerance. These changes in cardiovascular function are likely due to a combination of factors, including changes in ...
E M, Hasser, J A, Moffitt
openaire   +2 more sources

Artificial gravity training reduces bed rest-induced cardiovascular deconditioning

European Journal of Applied Physiology, 2011
We studied 15 men (8 treatment, 7 control) before and after 21 days of 6º head-down tilt to determine whether daily, 1-h exposures to 1.0 G(z) (at the heart) artificial gravity (AG) would prevent bed rest-induced cardiovascular deconditioning. Testing included echocardiographic analysis of cardiac function, plasma volume (PV), aerobic power (VO(2)pk ...
Michael B, Stenger   +8 more
openaire   +2 more sources

Beta blockade in the compensation for bed-rest cardiovascular deconditioning: Physiologic and pharmacologic observations

The American Journal of Cardiology, 1985
Beta-adrenergic blockade using intravenous propranolol was evaluated as a countermeasure for bedrest-induced cardiovascular deconditioning. After propranolol administration, tolerance to a maximal lower body negative pressure (LBNP) test after bed rest improved to at least the -70 mm Hg level; following this, there was a sharp decrease in tolerance ...
H, Sandler   +4 more
openaire   +2 more sources

The Effect of Complete and Partial Deconditioning on Exercise-Induced Cardiovascular Changes in the Rat

2015
Exercise conditioning of young male rats by swimming for 1 h, 5 times per week for 10 weeks results in a reduced gain in body weight, cardiac hypertrophy and hyperplasia, an increase in myocardial capillary density, and an increase in cross-sectional laminal areas of extracoronary collateral arteries.
A S, Leon, C M, Bloor
openaire   +2 more sources

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