Results 21 to 30 of about 1,138,845 (248)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Predictors of myocardial fibrosis and loss of epicardial adipose tissue volume in the long-term period after myocardial infarction

Российский кардиологический журнал, 2020
Aim. To assess the changes of biochemical markers in hospitalization, the relationship with the severity of myocardial fibrosis and the epicardial adipose tissue (EAT) thickness one year after myocardial infarction (MI).Material and methods.
O. L. Barbarash, O. V. Gruzdeva, T. B. Pecherina, O. E. Akbasheva, D. A. Borodkina, V. V. Kashtalap, V. N. Karetnikova, A. N. Kokov, N. K. Brel, Yu. A. Dyleva, E. V. Belik, E. G. Uchasova, E. E. Bychkova, A. A. Kuzmina   +13 more
doaj   +1 more source

Participation of the C-terminal propeptide procollagen type I in the formation of cardiofibrosis in patients with myocardial infarction with preserved left ventricular ejection fraction

Российский кардиологический журнал, 2021
Aim. To study the dynamics of procollagen type I carboxy-terminal propeptide (PICP) with an assessment of potential associations with cardiac fibrosis (CF) and diastolic dysfunction (DD) of the left ventricle (LV) during the hospitalization and one year ...
A. V. Osokina, V. N. Karetnikova, O. M. Polikutina, A. V. Ivanova, T. B. Pecherina, O. V. Gruzdeva, Yu. A. Dyleva, A. N. Kokov, N. K. Brel, O. L. Barbarash   +9 more
doaj   +1 more source

Predictors and Clinical Outcomes of Vasoplegia in Patients Bridged to Heart Transplantation With Continuous‐Flow Left Ventricular Assist Devices

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The presence of a durable left ventricular assist device (LVAD) is associated with increased risk of vasoplegia in the early postoperative period following heart transplantation (HT).
Rabea Asleh, Hilmi Alnsasra, Richard C. Daly, Sarah D. Schettle, Alexandros Briasoulis, Riad Taher, Shannon M. Dunlay, John M. Stulak, Atta Behfar, Naveen L. Pereira, Robert P. Frantz, Brooks S. Edwards, Alfredo L. Clavell, Sudhir S. Kushwaha   +13 more
doaj   +1 more source

Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice

Journal of Immunology Research, 2022
Diets rich in polyphenols are known to be beneficial for cardiovascular health. Gallic acid (GA) is a plant-derived triphenolic chemical with multiple cardio-protective properties, such as antiobesity, anti-inflammation, and antioxidation.
Jie Bai, Qiu-Yue Lin, Xiangbo An, Shuang Liu, Yao Wang, Yunpeng Xie, Jiawei Liao   +6 more
doaj   +1 more source

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source

INFLUENCE OF CARDIOVASCULAR DISEASES ON SALIVARY PARAMETERS

Romanian Journal of Medical and Dental Education, 2017
Cardiovascular diseases are a major group of diseases with increased prevalence among the population. Antihypertensive drugs are incriminated as responsible for reducing salivary flow and harm to oral health. The purpose of this study was to evaluate the
Carina Balcoș, Ramona Feier, Teona Tudorici, Norina Forna   +3 more
doaj  

Predictive accuracy of systolic blood pressure to left ventricular end-diastolic pressure ratio versus TIMI score for short-term mortality after primary percutaneous coronary intervention [PDF]

Journal of Cardiovascular and Thoracic Research
Introduction: Aim of this study was to evaluate the predictive performance of systolic blood pressure (SBP) to left ventricular end-diastolic pressure (LVEDP) ratio for the prediction of in-hospital and short-term mortality in a contemporary cohort of ...
Rajesh Kumar, Naveed Ullah Khan, Ali Bin Naseer, Zille Huma, Kalsoom Chachar, Maryam Samad, Muhammad Ishaq, Abiha Urooj, Uroosa Safdar, Muhammad Rasool, Sohail Khan, Jawaid Akbar Sial, Tahir Saghir, Nadeem Qamar   +13 more
doaj   +1 more source