Results 41 to 50 of about 1,479,964 (315)

Factors associated with poor outcomes after congenital heart surgery in low-resource setting in Pakistan: insight from the IQIC Registry – a descriptive analysis

BMJ Open, 2023
Objective This study aimed to assess the International Quality Improvement Collaborative single-site data from a developing country to identify trends in outcomes and factors associated with poor outcomes.Design Retrospective descriptive study.Setting ...
Muneer Amanullah, Abdul Sattar Shaikh, Shumaila Furnaz, Musa Karim, Rayyan Qureshi, Subhani Fatima, Sohail Khan Bangash   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Predictors and Clinical Outcomes of Vasoplegia in Patients Bridged to Heart Transplantation With Continuous‐Flow Left Ventricular Assist Devices

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The presence of a durable left ventricular assist device (LVAD) is associated with increased risk of vasoplegia in the early postoperative period following heart transplantation (HT).
Rabea Asleh, Hilmi Alnsasra, Richard C. Daly, Sarah D. Schettle, Alexandros Briasoulis, Riad Taher, Shannon M. Dunlay, John M. Stulak, Atta Behfar, Naveen L. Pereira, Robert P. Frantz, Brooks S. Edwards, Alfredo L. Clavell, Sudhir S. Kushwaha   +13 more
doaj   +1 more source

Small but smart-microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing

, 2011
With a progressively growing elderly population, ageing-associated pathologies such as cardiovascular diseases are becoming an increasing economic, social, and personal burden for Western societies.
Heymans, Stephane, Schroen, Blanche, S. Heymans, B. Schroen   +3 more
core   +1 more source

Nutraceutical Approaches to Cardiovascular and Metabolic Diseases: Evidence and Opportunities

, 2023
A major task for health professionals and health systems is effectively preventing and treating cardiovascular and metabolic diseases. This reprint offers an updated set of experimental and clinical information on the usefulness of nutraceutical products

core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Factors associated with in-hospital mortality after coronary artery bypass grafting in patients with CHD and type 2 diabetes

Сахарный диабет, 2014
Coronary artery bypass grafting (CABG) is the main method used for myocardial revascularisation in patients with diabetes mellitus (DM), and determining the factors affecting the outcomes of CABG in these patients is important. Objective.
Aleksey Nikolaevich Sumin, Natalya Alexandrovna Bezdenezhnykh, Andrey Viktorovich Bezdenezhnykh, Sergey Vasil'evich Ivanov, Ekaterina Vladimirovna Belik, Olga Leonidovna Barbarash   +5 more
doaj   +1 more source

Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice

Journal of Immunology Research, 2022
Diets rich in polyphenols are known to be beneficial for cardiovascular health. Gallic acid (GA) is a plant-derived triphenolic chemical with multiple cardio-protective properties, such as antiobesity, anti-inflammation, and antioxidation.
Jie Bai, Qiu-Yue Lin, Xiangbo An, Shuang Liu, Yao Wang, Yunpeng Xie, Jiawei Liao   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Radial or femoral access in primary percutaneous coronary intervention (PCI): Does the choice matters?

Indian Heart Journal, 2020
Background: This study was conducted with the aim of providing a quantitative appraisal of clinical outcomes of trans-radial access for primary percutaneous coronary interventions (PCI) in patients with ST-segment evaluation myocardial infarction (STEMI).
Mahesh Kumar Batra, Lajpat Rai, Naveed Ullah Khan, Muhammad Naeem Mengal, Sanam Khowaja, Syed Nadeem Hassan Rizvi, Tahir Saghir, Nadeem Qamar, Jawaid Akbar Sial, Musa Karim   +9 more
doaj   +1 more source