Results 51 to 60 of about 4,273,082 (313)

Forging Ahead in Cardiovascular Disease Management

, 2023
The common threat of cardiovascular diseases (CVDs) constantly holds a dominant position among the leading causes of global mortality [...
Michał Ciurzynski, Justyna Domienik-Karlowicz   +1 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experience in the development of a system for repeated prosthetic heart valves

Сибирский научный медицинский журнал, 2023
The failure of heart valve bioprostheses, requiring repeated intervention to replace them, is a serious drawback that narrows the scope of such devices.
E. A. Ovcharenko, K. Yu. Klyshnikov, A. N. Stasev, A. V. Evtushenko, I. K. Khalivopulo, D. V. Borisenko, T. V. Glushkova, A. V. Ivanova, I. V. Dvadtsatov, S. S. Krutitsky, Yu. A. Kudryavtseva, O. L. Barbarash, L. S. Barbarash   +12 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Predictors and Clinical Outcomes of Vasoplegia in Patients Bridged to Heart Transplantation With Continuous‐Flow Left Ventricular Assist Devices

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The presence of a durable left ventricular assist device (LVAD) is associated with increased risk of vasoplegia in the early postoperative period following heart transplantation (HT).
Rabea Asleh, Hilmi Alnsasra, Richard C. Daly, Sarah D. Schettle, Alexandros Briasoulis, Riad Taher, Shannon M. Dunlay, John M. Stulak, Atta Behfar, Naveen L. Pereira, Robert P. Frantz, Brooks S. Edwards, Alfredo L. Clavell, Sudhir S. Kushwaha   +13 more
doaj   +1 more source

Results of preclinical trials in a sheep model of biodegradable small-diameter vascular grafts

Вестник трансплантологии и искусственных органов, 2022
Surface modification of polymer vascular matrices is a promising development for preventing vascular graft thrombosis, improving long-term patency and accelerating remodeling. Objective: to study the outcomes of long-term patency of PHBV/PCL/GFmix grafts
L. V. Antonova, E. O. Krivkina, M. Yu. Khanova, E. A. Velikanova, V. G. Matveeva, А. V. Mironov, A. R. Shabaev, Е. A. Senokosova, T. V. Glushkova, M. Yu. Sinitsky, R. А. Mukhamadiyarov, L. S. Barbarash   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

COPD and Cardiovascular Disease

Pulmonology, 2019
COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020. COPD and cardiac comorbidities are frequently associated.
André, S., Conde, B., Fragoso, E., Boléo-Tomé, J.P., Areias, Vanda, Cardoso, J.   +5 more
openaire   +6 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Nutrition, metabolism and cardiovascular diseases

Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders.
Borghi C
core   +2 more sources