Results 151 to 160 of about 886,388 (315)

Cardiovascular and noncardiovascular mortality among patients starting dialysis.

, 2009
CONTEXT: Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population.
Wetzels, J.F.M., Jager, Kitty J., Jager, D.J. de, van Dijk, Paul C., Finne, Patrik, Dekker, Friedo W, Rosendaal, F.R., Dekker, F.W., Heaf, J.G., de Meester, Johan, Heaf, James G, Dekker, Friedo W., Collart, Frederic, Wetzels, Jack F. M., Wetzels, Jack F M, Rosendaal, Frits R, van Dijk, Paul C, Grootendorst, D.C., Dijk, P.C. van, Ansell, D., Grootendorst, Diana C., Ansell, David, Jager, K.J., Tomas, Lonneke M J, Finne, P., Tomas, Lonneke M. J., Grootendorst, Diana C, de Jager, Dinanda J, Rosendaal, Frits R., Meester, J. de, Jager, Kitty J, Tomas, L.M., de Jager, Dinanda J., Collart, F., Heaf, James G.   +34 more
core   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Association Between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality and Cardiovascular Events in Patients with Diabetic Foot Ulcers: A Retrospective Cohort Study

Journal of Inflammation Research
Maolin Tian, Lulu Liu, Yukun Tao, Jinzheng Hou, Guangxin Zhou, Li Xiao, Huijuan Zhu, Di Zhu, Da Zhang Department of Endocrinology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, People’s Republic of ChinaCorrespondence: Di Zhu ...
Tian M, Liu L, Tao Y, Hou J, Zhou G, Xiao L, Zhu H, Zhu D, Zhang D   +8 more
doaj  

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Non-linear associations of triglyceride glucose index with all-cause and cardiovascular mortality in patients with heart failure

Diabetology & Metabolic Syndrome
Background The relationship between triglyceride glucose (TyG) index and long-term prognosis in individuals with heart failure (HF) remains unclear. This study aimed to explore the relationship between the TyG index and both all-cause and cardiovascular ...
Huanhuan Miao, Zhanyang Zhou, Zheng Yin, Yuhui Zhang, Yuqing Zhang, Jian Zhang   +5 more
doaj   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

Autopsy on an Empire: Understanding Mortality in Russia and the Former Soviet Union [PDF]

Male life expectancy at birth fell by over six years in Russia between 1989 and 1994. Many other countries of the former Soviet Union saw similar declines, and female life expectancy fell as well. Using cross-country and Russian household survey data, we
Elizabeth Brainerd, David M. Cutler
core   +2 more sources

Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis

Diabetology & Metabolic Syndrome
Background The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both cardiovascular diseases and mortality.
Mehrdad Rabiee Rad, Ghazal Ghasempour Dabaghi, Hossein Sadri, Bahar Darouei, Reza Amani-Beni, Sadegh Mazaheri-Tehrani   +5 more
doaj   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Evaluating body roundness index and systemic immune inflammation index for mortality prediction in MAFLD patients

Scientific Reports
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major cause of liver-related morbidity and mortality, contributing to both cardiovascular and non-cardiovascular deaths.
Di Zeng, Qingyue Zeng, Shuangqing Li, Jiong Lu, Nansheng Cheng   +4 more
doaj   +1 more source