Results 131 to 140 of about 840,504 (265)

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Mental Distress and Smoking in Relation to Cardiovascular Mortality in the United States Population. [PDF]

Brain Behav
Wang S, Xiong YJ, Meng XD, Lv T, Lou J.
europepmc   +1 more source

Revisiting the BMI-based obesity paradox in mortality risk across the cardiovascular-kidney-metabolic syndrome continuum

Jian Lu, Shuaigang Sun, Shunwei Wang, Zekai Deng, ChenPing Wei, Shimin Jiang, Wenge Li   +6 more
openalex   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Associations of triglyceride-glucose-obesity composite indices with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3 and their potential incremental value beyond a PREVENT-variable-based model

Hongwei Wang, Caizheng Yang, Shanshan Ge, Ruihua Jin, Xinyu Wang, Zhonglin Hao, Xueyu Wang, Ming Zhao, Hua He, Fangying Tian   +9 more
openalex   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Differential association of hypothyroidism with cardiovascular events and cardiovascular mortality: a systematic review and meta-analysis. [PDF]

Endocrine
Gatta E, Delbarba A, Vizzardi E, Rotondi M, Cappelli C.   +4 more
europepmc   +1 more source

Health risks and lag effects of ambient PM2.5 exposure on respiratory and cardiovascular mortality and morbidity in Ratchaburi, Thailand [PDF]

Sitthipong Pengjan, Sébastien Bonnet, Savitri Garivait   +2 more
openalex   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

The Role of Lipid Disorders in Cardiovascular Mortality Among Saudis: A Review Perspective. [PDF]

Int J Endocrinol
Alsaidan AA.
europepmc   +1 more source