Results 111 to 120 of about 886,388 (315)

Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality [PDF]

, 2013
OBJECTIVE: To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis
McKnight, J., Walker, Jeremy J., Morris, A., Sattar, N, Sattar, N., Wild, S., McKnight, J, Philip, Sam, Morris, Andrew, Wild, Sarah, Lindsay, R., Leese, Graham, Walker, JJ, Leese, G, McKnight, John, Group, Scottish Diabetes Research Network Epidemiology, Morris, A, Walker, J.J., Lindsay, Robert, Leese, G., Sattar, Naveed, Logue, J., Philip, S, Logue, J, Wild, Sarah; id_orcid, ?, ?, Logue, Jennifer, Walker, Jeremy J, Philip, S., Lindsay, R, Wild, S   +30 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer.

Although metrics of cardiovascular health have been associated with improved mortality, whether the association remains among individuals with a history of cancer has not been well characterized.
Ofer Kobo, Dmitry Abramov, Abramov, Dmitry, Kobo, Ofer, Mamas, Mamas A, Mamas A. Mamas   +5 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Association of age at menopause with cardiovascular disease and mortality:insights from NHANES and a clinical cohort

Frontiers in Cardiovascular Medicine
BackgroundAge at menopause is closely associated with cardiovascular disease and mortality, whereas the underlying mechanisms remain unclear. This study employed mediation analysis to explore potential pathways underlying this association.MethodsNatural ...
Xinmiao Hong, Xinmiao Hong, Linxi Jin, Linxi Jin, Guoli Shang, Guoli Shang, Qiwei Chen, Qiwei Chen, Zhuang Han, Zhuang Han, Shuhong Yao, Shuhong Yao, Zhita Wang, Liang Li, Weidong He, Xianpei Heng, Liuqing Yang   +16 more
doaj   +1 more source

Long-term lifestyle and dietary habits in relation to cardiovascular mortality and life expectancy: a prospective cohort study

, 2009
Introduction: In prospective cohort studies, information on lifestyle and dietary habits is generally only assessed at the baseline examination, assuming that these habits are relatively constant over the entire study period.
Streppel, M.T.
core  

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Employment of the Albumin to Alkaline Phosphatase Ratio to Predict All-cause Mortality and Cardiovascular and Cerebrovascular Mortality in Adults Aged At Least 60 Years: An Analysis From NHANES 2003–2018

Reviews in Cardiovascular Medicine
Background: The relationship between the albumin-to-alkaline phosphatase ratio (AAPR) and all-cause and cardiovascular and cerebrovascular mortalities, in adults aged 60 years and above, remains unclear.
Zhen Tan, Mei Zhang, Lei Liu, Shuang Li, Xinrui Xue, Yijun Liu, Hongqiang Ren   +6 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source