Results 81 to 90 of about 549,307 (260)

From Editor-in-chief: On current issue, our policies, diversity and outstanding reviewers for year 2022, interesting trials, consensus documents, and long COVID

Heart Vessels and Transplantation, 2023
Gulmira Kudaiberdieva
doaj   +1 more source

Comparative Performance of Multimodal and Unimodal Large Language Models Versus Multicenter Human Clinical Experts in Aortic Dissection Management

Diagnostics
Background: Multimodal large language models (MLLMs) integrating multiple AI systems and unimodal large language models (LLMs) represent distinct approaches to clinical decision support.
Evren Ekingen, Mete Ucdal
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Exploring the perioperative experiences of youth undergoing cardiac surgery: A qualitative needs assessment for tailoring a mobile self-management app

Journal of Clinical and Translational Science
Introduction: One in five children who undergo cardiac surgery report experiencing moderate to severe pain lasting more than 3 months after surgery which has a significant impact on quality of life.
Tieghan Killackey, Jill O’Hare, Sandra Merklinger, Lauren Harris, Mansi Patel, Nicole Drumm, Selini Jayawickrema, Fiona Campbell, Katherine Taylor, Jennifer Russell, Rachel D. Vanderlaan, Fareha Nishat, Laura Veloso, Maya Samarasekera, Jennifer N. Stinson   +14 more
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Mapping surgical deserts of cardiovascular training in Latin America: A geospatial and structural analysisCentral MessagePerspective

JTCVS Open
Objective: Latin America faces significant disparities in cardiovascular surgery training access. We used a driven geospatial analysis to map surgical deserts—underserved regions to surgical education—and quantified disparities through population ...
Wildor Samir Cubas, MD, MSc, Joaquín Gundelach, MD, Lorena Montes, MD, Maximiliano Hernández, MD, Santiago Cubas, MD, Carolina Sosa Vota, MD, Juan Andrés Montero, MD, Gerardo Soca, MD, MSc, Víctor Dayan, MD, PhD, Michael W.A. Chu, MD, MEd   +9 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Effect of Erector Spinae Plane Block on Intraoperative Hemodynamics and Oxygenation Status in Patients Undergoing Cardiac Surgery via Median Sternotomy

Український журнал серцево-судинної хірургії
Relevance. Recently, the erector spinae plane block (ESPB) has been used as a component of multimodal analgesia (MMA) in cardiac surgery. However, the impact of ESPB on hemodynamics and oxygenation status in patients remains insufficiently studied ...
Ruslan M. Taran, Serhii I. Vorotyntsev
doaj   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source