Results 181 to 190 of about 866,900 (297)

TEG ® 6s Heparin Neutralization Cartridge for Hemostatic Assessment of Patients Undergoing Cardiovascular Surgery. [PDF]

Anesthesiology
Adelmann D, Hartmann J, Moore HB, Yockelson SR, Dageforde LA, Chitilian H, Little MB, Bliden KP, Gurbel PA, Tantry US, Subramaniam K, Sakai T.   +11 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Clinical characteristics and outcomes of cardiovascular surgery and transcatheter procedures in adults with Down syndrome and congenital heart disease. [PDF]

Int J Cardiol Congenit Heart Dis
Osawa T, Machino-Ohtsuka T, Kume K, Yano T, Kanaoka K, Sumita Y, Yano Y, Numata R, Kawamatsu N, Kato H, Hiramatsu Y, Ishizu T.   +11 more
europepmc   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Sivelestat and Incidence of Acute Respiratory Distress Syndrome After Cardiovascular Surgery: A Randomized Clinical Trial.

JAMA Netw Open
Pan T, Xu C, Wang YP, Wang HL, Su WX, Zhang HT, Zhu EJ, Li YT, Lv ZK, Zhu TT, Xu ZW, Gao Y, Xu CZ, Shi J, Ji WJ, Duan ZH, Zhang C, Xu ZJ, Li KS, Chong H, Zhu XY, Xue YX, Xu WZ, Chen C, Zhao WW, Ye JX, Ge M, Xu GJ, Wu SM, Pan J, Wang DJ, Qu JZ, Wang Q.   +32 more
europepmc   +1 more source

Hyperbaric oxygen therapy for cardiovascular surgery. [PDF]

Med Gas Res
Wang D, Liu M, Jia S, Tian Z, Yang J, Liu X.   +5 more
europepmc   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Hemodynamic Management with Vasopressin for Cardiovascular Surgery. [PDF]

Medicina (Kaunas)
Kato H, Mathis BJ, Shimoda T, Nakajima T, Tokunaga C, Hiramatsu Y.   +5 more
europepmc   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Bleeding After Cardiovascular Surgery: A Continuing Problem. [PDF]

Circulation
Sellke FW.
europepmc   +1 more source