TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao +12 more
wiley +1 more source
Identification and resolution of drug-related problems in the cardiovascular surgery unit of a tertiary hospital in China: a retrospective study. [PDF]
Li BX +4 more
europepmc +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Experiences of Cardiovascular Surgery Intensive Care Nurses in the Care of Patients With Postoperative Cognitive Dysfunction: A Qualitative Study. [PDF]
Azizoğlu H.
europepmc +1 more source
Problems after Cardiovascular Surgery in Intensive Care Unit and Nursing Care
Tuğba ÇAM YANIK, Seher Gürdil Yılmaz
openalex +1 more source
Budget Impact Analysis of Implementing Patient Blood Management in the Cardiovascular Surgery Department of a Turkish Private Hospital. [PDF]
Tatar M +4 more
europepmc +1 more source
Oral Health Clearance Outcomes for Cardiovascular Surgery. [PDF]
Zhou MX +5 more
europepmc +1 more source
The long-term success of cardiovascular surgery in Takayasu arteritis: 48 years of experience in Mexico, beyond forefront techniques. [PDF]
Soto ME +9 more
europepmc +1 more source
Vascular access and closure management for electrophysiological interventions in 2025: a Clinical Consensus Statement of the European Heart Rhythm Association and the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the ESC Working Group on Cardiovascular Surgery. [PDF]
De Potter TJR +23 more
europepmc +1 more source

