Results 51 to 60 of about 293,276 (262)

Perspectives on Coordinating Health Services for Individuals with Serious Mental Illness – A Qualitative Study

Journal of Multidisciplinary Healthcare, 2022
Jorunn Nærland Skjærpe,1 Inge Joa,1,2 Elisabeth Willumsen,1 Wenche ten Velden Hegelstad,2,3 Tatiana Aleksandrovna Iakovleva,4 Marianne Storm1,5 1Department of Public Health, Faculty of Health Science, University of Stavanger, Stavanger, Norway; 2TIPS ...
Skjærpe JN, Joa I, Willumsen E, Hegelstad WTV, Iakovleva TA, Storm M   +5 more
doaj  

Implementation and evaluation of a novel integrated care program in South Eastern Sydney, Australia

International Journal of Integrated Care, 2019
Background: Integrated Care in Australia has mostly been implemented as micro-level initiatives rather than systemically, which has challenged its sustainability [1].
Julie Osborne, Brendon McDougall, Sonia Van Gessel, Anna McGlynn, Karen Patterson, Jane Cockburn, Amy Young, Jan Sadler, Catherine Scardilli, Sameera Ansari, Ben Harris-Roxas, Anthony Jackson, Greg Stewart   +12 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Responsible coordination of municipal health and care services: Café dialogues as a method for responsible innovation [PDF]

, 2023
Jorunn Nærland Skjærpe, Tatiana Iakovleva, Marianne Storm   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Implementing a Pharmacist-Led Medication Management Pilot to Improve Care Transitions

INNOVATIONS in Pharmacy, 2012
Purpose: The purpose of this project was to design and pilot a pharmacist-led process to address medication management across the continuum of care within a large integrated health-system.
Rachel Root, Pamela Phelps, Amanda Brummel, Craig Else   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

New Donor Selection Criteria Result in Optimal Outcomes of Kidneys from Uncontrolled Donation After the Circulatory Determination of Death

Transplantation Direct
Background. The aim of our study is to share our experience with uncontrolled donation after the circulatory determination of death (uDCDD) kidney transplantation and to propose updated donor selection criteria for uDCDD programs. Methods.
Sandra Campos, MD, Maria Angeles Ballesteros, MD, PhD, Emilio Rodrigo, MD, PhD, Covadonga López del Moral, MD, Félix Campos-Juanatey, MD, Borja Suberviola, MD, PhD, Lucía García-Alcalde, MD, Aurora Amaya, MD, Beatriz Domínguez-Gil, MD, PhD, Juan Carlos Ruiz-San Millan, MD, PhD, Eduardo Miñambres, MD, PhD   +10 more
doaj   +1 more source