Results 61 to 70 of about 4,149,654 (191)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

New Professional Approaches for Care Leaver in Foster Care: Training “Coaching to Go!”

Lubelski Rocznik Pedagogiczny
Introduction: The number of young people with limited or non-existent social participation is growing. Characteristic is the proportion of young homeless individuals who had previous institutional contact with youth welfare.
Robert Frietsch, Dirk Holbach, Corinna Leißling   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Developing Employment Opportunities for Care Leavers [PDF]

, 2010
This article describes an action research project carried out in North West England that aimed to assist Children’s Services Departments and Care Trusts in developing their strategies for supporting care leavers into employment and training.
Bilson, Andy, Price, Joanna, Stanley, Nicky   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pledge of Pride:Exploring the Experiences of LGBTQ+ Care Leavers [PDF]

, 2023
This resource has been produced as an output from the Leaving Care With Pride research project. The project aimed to address the dearth in knowledge exploring multiple intersecting disadvantages that UK lesbian, gay, bisexual, trans and queer (LGBTQ ...
Andrew, Charlotte, Zari, Syed, S, Brett, Brown, Claire; id_orcid, Smith, Jack   +4 more
core   +1 more source

Wohnen und Selbständigkeit. Institutionelle Unterstützung prekärer Übergänge ins Erwachsenenalter.

Schweizerische Zeitschrift für Soziale Arbeit, 2020
Verschiedene Studien aus dem Ausland zeigen, dass Jugendliche und junge Erwachsene, die aus Institutionen der Jugendhilfe oder Pflegefamilien in die Selbstständigkeit entlassen werden (Care Leavers), ein erhöhtes Risiko haben, mit Problemen wie ...
Renate Stohler, Milena Gehrig
doaj  

The role of informal networks in the lives of young people transitioning from care: a review of the literature

Scottish Journal of Residential Child Care, 2021
Young people leaving the care system face significant challenges when making the transition to adulthood, with limited support from other agencies. Their outcomes are significantly poorer than those of their non-care peers. This review aims to synthesise
Philip Teer
doaj   +1 more source