Results 51 to 60 of about 5,997,028 (302)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A literature review to explore integrated care for older people [PDF]

, 2005
Purpose: This paper reports on some of the findings of a literature review commissioned to explore integrated care for older people. Methods: The process of revising included finding and selecting literature from multidisciplinary sources, and ...
Sue Childs, Childs, Sue, Reed, Jan, Cook, Glenda, McCormack, Brendan, Jan Reed, Brendan McCormack, Glenda Cook   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Care Pathway Concept: concepts and theories: an introduction

International Journal of Integrated Care, 2012
This article addresses first the definition of a (care) pathway, and then follows a description of theories since the fifties of the last century.  It ends with a discussion of theoretical advantages and disadvantages of care pathways for patients and ...
Guus Schrijvers, Arjan van Hoorn, Nicolette Huiskes   +2 more
doaj  

Pathways to and through caring:

This chapter provides an overview of how the socioeconomic background of caregiving dyads influences family carers’ decisions and motivations for caring, as well as their ability to organise and navigate the provision of care for older adults in Slovenia.
Potočnik, Tjaša, Filipovič Hrast, Maša, Hurtado Monarres, Miriam, Hlebec, Valentina   +3 more
openaire   +1 more source

A checklist for patient safety rounds at the care pathway level. [PDF]

, 2014
Objective: To define a checklist that can be used to assess the performance of a department and evaluate the implementation of quality management (QM) activities across departments or pathways in acute care hospitals.
Kristensen, S, Pfaff, Holger, Ommen, O, Pfaff, H, Bottaro, S., Wang, A., Lívio, A., Suñol, R., Shaw, C., Plochg, T, Kristensen, S., Depaigne-Loth, A., Depaigne-Loth, A, Kutaj-Wasikowska, H, Kus, H, Secanell, M., Klazinga, N.S., Mannion, Russell, Ozturk, K., Bruneau, Charles, Leite, I, Botje, D, Groene, Oliver, Kutryba, B, Saillour-Glenisson, F, Garel, Pascal, Almeman, F., Lívio, A, Eiras, M, Wang, A, Kutryba, Barbara, Arah, O.A., Suñol, Rosa, Franca, M, Klazinga, N.S, Thompson, Caroline A., Saluvan, M, Hammer, A., Almeman, F, Bartels, Paul, Jones, S., Kringos, DS, Secanell, M, Wagner, C., Groene, O., Garel, P, Dersarkissian, Maral, Groene, O, Thompson, C.A., Kutaj-Wąsikowska, Halina, Leite, I., Lopez, MA, Arah, OA, Botje, Daan, Suñol Sala, Rosa, Thompson, Caroline A, Wagner, C, Kus, H., Vlcek, Frantisek, Franca, M., DerSarkissian, M., Escoval, Ana, Jones, S, Thompson, A, Car, M., Klazinga, Niek S, Lombarts, M.J.M.H., Escoval, A, Eiras, M., Wagner, Cordula, Bartels, P, Plochg, Thomas, Shaw, C, Dersarkissian, M, Arah, Onyebuchi A, Klazinga, N, Lombarts, M.J.M.H, Kringos, Dionne, Klaus, E, Arah, Onyebuchi A., Bruneau, C, Vallejo, P., Thompson, A., Lombarts, MJMH, Car, M, Vlcek, F, Ommen, O., Saluvan, M., Thompson, CA, Klaus, E., Bottaro, S, Suñol, R, Saillour-Glenisson, F., Arah, O.A, Vallejo, P, Lopez, M. A., Klazinga, Niek S., Mannion, R, Michel, P, Ozturk, K, Lopez, M.A, Kringos, D.S, Thompson, C.A, Hammer, A, Michel, P.   +104 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source