Results 71 to 80 of about 5,997,028 (302)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Distance et recours à l’expertise en cancérologie. Expérience des contraintes géographiques chez des patients du Centre Léon Bérard (Lyon)

Espace populations sociétés, 2018
While patients with chronic illnesses may be obliged to travel long distances to access health care, the impact of this distance on their quality of life remains relatively little studied.
Virginie Chasles, Yohan Fayet, Aurélie Juvanon   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Impact of a care pathway for COPD on adherence to guidelines and hospital readmission: a cluster randomized trial

International Journal of COPD, 2016
Kris Vanhaecht,1,2 Cathy Lodewijckx,1 Walter Sermeus,1 Marc Decramer,3,4 Svin Deneckere,1,5 Fabrizio Leigheb,6 Paulo Boto,7 Seval Kul,8 Deborah Seys,1 Massimiliano Panella1,6 1Department of Public Health and Primary Care, Leuven Institute for Healthcare
Vanhaecht K, Lodewijckx C, Sermeus W, Decramer M, Deneckere S, Leigheb F, Boto P, Kul S, Seys D, Panella M   +9 more
doaj  

Que faire de ce cancer ?

Temporalités
Is the trial of cancer, when it occurs at an advanced age, primarily a trial of time? While most elderly individuals recently diagnosed with cancer are inclined to pursue treatment, for others, this commitment is not as straightforward.
Clément Desbruyères
doaj   +1 more source

Prison Health Discharge Planning- Evidence of an integrated care pathway or the end of the road? [PDF]

, 2013
This article is based on research conducted in several prisons in North East England. It explores the effectiveness of prisons, and the wider criminal justice system, at meeting the healthcare needs of inmates as they leave prison, or transfer between ...
Northumbria University, Biddle, Paul, Dyer, Wendy   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Regional Integrated Cardiovascular Risk Management Care Pathway in the Netherlands: Benefits and Working Mechanisms

International Journal of Integrated Care
Background: Integrated cardiovascular risk management care pathways are initiated nationwide to decrease the morbidity, mortality, and costs of cardiovascular diseases.
Relinde J. de Koeijer, Marcella E. de Geest, Gideon R. Hajer, Fabrice M. A. C. Martens   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Professionals' Perceptions of the Colorectal Cancer Pathway: Results of a Co‐Constructed Qualitative Study

Health Expectations
Introduction Qualitative research on the perceptions of healthcare professionals involved in cancer care about their respective roles in the patient care pathway is limited.
Matthieu Delaye, Alice Polomeni, Sylvie Faiderbe, Nadège Berlioz, Chaïma Benssekoum, Aude Guillemin, Thomas Pudlarz, Sandrine deMontgolfier   +7 more
doaj   +1 more source