Results 91 to 100 of about 395,980 (266)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Applied and Computational MechanicsThe present study unveils research that examines the laminar motion of water-infused nanofluid comprised of nanoparticles of TiO2 (titanium dioxide), Ag (silver), and Cu (copper) over a stretching sheet. The flow undergoes a novel slip condition based on
Singh B., Sood S., Thakur A., Chandel S.
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Career Capital and Career Habitus: Career and Workplace Learning
Journal of Lifelong Learning Society, 2013 경력 연구는 다양한 학분 분야에서 서로 다른 이론적 실천적 연구 관심들을 가지며 발달해왔으며, 크게는 개인의 직업생활 준비 과정과 입직 이후 직업생활의 두 시기가 구분되어 각각 진로와 경력이라는 용어로 분리되어 전개되어 왔다. 이 연구에서는 경력을 개인 차원과 사회 환경 차원으로 구분하는 이분법적 관점을 극복하기 위하여 경력에 대한 개인과 사회 맥락간의 상호작용을 강조하는 이론적 관점이 필요하다는 문제의식에서 출발하였다. 특히 탈조직 맥락의 경력 환경에서의 개인의 주체적인 경력개발을 강조하게 된 최근의 경력 논의는 개인의 경력 역량 개발의 중요성을 강조하고 있다.
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Careering Bureaucrats and Bureaucrats' Careers [PDF]
German Journal of Human Resource Management: Zeitschrift für Personalforschung, 2012 openaire +2 more sources