Results 51 to 60 of about 376,533 (265)
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Fluid Ability (Gf) and Complex Problem Solving (CPS)
Complex problem solving (CPS) has emerged over the past several decades as an important construct in education and in the workforce. We examine the relationship between CPS and general fluid ability (Gf) both conceptually and empirically.
Patrick Kyllonen +2 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In a business environment characterised by growing pressure towards sustainability and digital transformation, leadership emerges as a determining factor in the adoption of sustainable, technology-driven business models.
Dalia Sanchez +2 more
doaj +1 more source
Standardized driving cycles such as the FTP-75 fail to represent traffic conditions in cities like Guayaquil, where high congestion and varied driving behaviors are not captured by external models.
Roberto López-Chila +3 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Urban air pollution and emission reduction commitments have stimulated interest in cleaner vehicle technologies in Latin America, yet hybrid vehicle penetration in Ecuador, particularly in Guayaquil, remains limited.
Emerson Altamirano-Cañizares +3 more
doaj +1 more source

