Results 51 to 60 of about 382,232 (265)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

ECNEUROCOG PROJECT: VALIDATION AND STANDARDIZATION OF AN ATTENTIONAL TASK IN THE ECUADORIAN POPULATION

IBRO Neuroscience Reports, 2023
Jorge Gordón - Rogel, Anabela Galarraga - Andrade, Evelyn Torres Collaguazo, María Estévez Narváez, Melany Almedáriz Donoso, David Mejía Espinosa, Juan Ruíz Báez, Eliecer Chandi Díaz   +7 more
doaj   +1 more source

Fluid Ability (Gf) and Complex Problem Solving (CPS)

Journal of Intelligence, 2017
Complex problem solving (CPS) has emerged over the past several decades as an important construct in education and in the workforce. We examine the relationship between CPS and general fluid ability (Gf) both conceptually and empirically.
Patrick Kyllonen, Cristina Anguiano Carrasco, Harrison J. Kell   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

VALIDATION OF ATTENTIONAL NEUROPSYCHOLOGICAL TEST WITH SOCIODEMOGRAPHIC CONSIDERATIONS IN THE ECUADORIAN POPULATION

IBRO Neuroscience Reports, 2023
Anabela Galarraga - Andrade, Jorge Gordón - Rogel, María Estévez Narváez, Melany Almedáriz Donoso, Evelyn Torres Collaguazo, Eliecer Chandi Díaz, David Mejía Espinosa, Juan Ruíz Báez   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Influence of leadership on the adoption of circular and digital business models using PLS-SEM analysis

Scientific Reports
In a business environment characterised by growing pressure towards sustainability and digital transformation, leadership emerges as a determining factor in the adoption of sustainable, technology-driven business models.
Dalia Sanchez, Analí Sulca, Liz Pacheco-Pumaleque   +2 more
doaj   +1 more source

Development of Representative Urban Driving Cycles for Congested Traffic Conditions in Guayaquil Using Real-Time OBD-II Data and Weighted Statistical Methods

Vehicles
Standardized driving cycles such as the FTP-75 fail to represent traffic conditions in cities like Guayaquil, where high congestion and varied driving behaviors are not captured by external models.
Roberto López-Chila, Henry Abad-Reyna, Joao Morocho-Cajas, Pablo Fierro-Jimenez   +3 more
doaj   +1 more source

A Huge Adenomatoid Odontogenic Tumor of Maxilla

Case Reports in Medicine, 2012
The adenomatoid odontogenic tumor (AOT) is a benign, nonneoplastic (hamartomatous) lesion with a slow progressing growth. It occurs in both intraosseous and peripheral forms.
Balasundari Shreedhar, Iqbal Ali, Anshita Agarwal, Sarwar Alam   +3 more
doaj   +1 more source