Results 71 to 80 of about 376,533 (265)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Anti-HIV drugs (emtricitabine and lamivudine) mediated micellization behavior of anionic and cationic surfactants: A thermodynamic investigation

Chemical Physics Impact
Aggregation behavior of conventional surfactants; SDS (anionic) and CTAB (cationic) in aqueous medium has been investigated in the presence of anti-HIV drugs; Emtricitabine (ECT) and Lamivudine (LMV) using conductometry, UV–Visible spectroscopy, and ...
Richa Sharma, Suvarcha Chauhan, Naveen Thakur, Kuldeep Kumar   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Beyond the Game: Exploring the Interplay of Career Thoughts, Career Adaptability, and Athletic Identity in Shaping Postgraduation Paths for Student Athletes

Journal of Postsecondary Student Success
College student athletes represent a unique subpopulation of university students. Balancing expectations for academics, practice, and performance leaves little time to engage in thoughtful career exploration and postgraduate planning.
Ryan Sides, Debra S. Osborn, Ivey Walker, Jacob Stamm, Bobbi Villarreal   +4 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Deconstructing barriers to support Japanese students in group discussion

The Asia Pacific Scholar, 2022
Kiyotaka Yasui, Maham Stanyon, Yoko Moroi, Shuntaro Aoki, Megumi Yasuda, Koji Otani , Yayoi Shikama   +6 more
doaj   +1 more source

Numerical analysis of mixed convection and Thomson-Troian slip effects on ternary nanofluid flow and heat transfer over a stretching sheet with porous media: Darcy-Forchheimer model

Applied and Computational Mechanics
The present study unveils research that examines the laminar motion of water-infused nanofluid comprised of nanoparticles of TiO2 (titanium dioxide), Ag (silver), and Cu (copper) over a stretching sheet. The flow undergoes a novel slip condition based on
Singh B., Sood S., Thakur A., Chandel S.
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Career development

, 2011
Career development is a lifelong endeavor that starts in childhood and usually ends in old age after retirement from paid work. We discuss career development as the interplay of individual social and institutional contexts. The first chapter treats theoretical perspectives on Career Development. Then transition was discussed as a challenge.
Neuenschwander Markus P., Kracke Bärbel
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source