Results 111 to 120 of about 853,686 (274)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Work Engagement: A Calling or Career?

The primary objective of this research was to examine the functional relationship of employee engagement of the present occupational choice as a career or calling. In accordance, the career or calling attributes and UWES work engagement were applied to a
Maria Dinna P. Avinante, Margarita J. Mangalile, Ma. Flordeliza L.Anastacio, Nilo V. Francisco   +3 more
core   +2 more sources

The influence of community social capital on pre-service teachers’ career calling: the mediating role of career exploration and the moderating effect of agreeableness

Frontiers in Education
IntroductionThis study aims to explore the mechanism by which community social capital influences pre-service teachers’ career calling, while also examining the mediating role of career exploration and the moderating effect of agreeableness.MethodsData ...
Xiaomin Su, Anuar Ahmad, Jamsari Alias
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

What Happened to Your Calling? The Development of Calling Across College-To-Work Transition

Career calling is a pervasive, purposeful, transcendent, and passion-driven approach to a job that is perceived as central to individuals' identity, that contributes to the greater good, and for which individuals are willing to make sacrifices.
Dalla Rosa, A, Gerdel, S, Vianello, M
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The association between high-performance work systems and career calling among intensive care unit nurses: the roles of job crafting and thriving at work

Frontiers in Psychology
BackgroundCareer calling is an important psychological resource that helps sustain nurses’ commitment to their profession, particularly in intensive care unit (ICU) settings where workforce turnover remains a persistent challenge.
Min Chen, Huizi Wang, Yue Ling, Hongbin Zhu, Yuqin Liu, Yue Yuan, Cuiping Xu   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Career Calling and Burnout in the Auxilium Social Cooperative

, 2022
reservedLa chiamata professionale è un costrutto multidimensionale presentato attraverso il modello teorico della Work as a Calling Theory. Il presente studio intende analizzare il rapporto tra Chiamata professionale e Burnout all'interno della ...
FACENDOLA, ANGELA
core  

Linking proactive motivation to search for and presence of calling among kindergarten teachers: a variable-centered and person-centered approach

BMC Psychology
Teachers’ calling is a key psychological resource in education, encompassing search and presence. Based on the Proactive Motivation Model, calling is influenced by “can do,” “reason to,” and “energized to” motivational states.
Wenjing Zeng, Runkai Jiao, Dandan Huang, Zhengya Teng, Feifei Li   +4 more
doaj   +1 more source