Results 121 to 130 of about 111,585 (300)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Education and Employment: the influences on young people’s career decision making in Antigua and the UK [PDF]
The thesis looks at the issue of career choice and decision-making through the eyes of young people in Antigua and in England. It provides an account of their views and attitudes in relation to various jobs and careers and the factors which have ...
Swift, John
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Personality and achievement motivation as determinants of career choice [PDF]
, 2012 The purpose of this study was to examine the relationship between personality, achievement motivation, and career choice. One hundred and thirty six participants recruited through the psychology subject pool at Murdoch University and through snowball ...
Glaser, Robyn
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Вестник Московского университета. Серия 14: ПсихологияBackground. The career intentions of students are of great importance in the context of the acute practical problem of medical graduates’ employment in health care organisation, but their psychological factors are still understudied. Objective.
Oleg A. Sychev +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Men in non-traditional occupations: Career entry, career orientation and experience of role strain [PDF]
, 2006 This paper sets out to explore the experiences of men in non-traditional occupations. In particular it focuses on the dynamics of career entry, career orientation (i.e. preference for intrinsic or extrinsic rewards) and the possible existence, nature and
Simpson, R
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Protean and Boundaryless Career Attitudes in New Zealand Workers [PDF]
, 2010 This study explored protean and boundaryless career attitudes in a sample of New Zealand workers. Recent changes to both organisational and societal structures have significantly altered how careers are acted out.
Morrell, Heather Rebecca
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