Results 101 to 110 of about 1,258,808 (299)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Chain-mediated effects of career self-efficacy and career planning between social support and career anxiety in college soccer players

Frontiers in Psychology
The purpose of this study was to investigate the factors affecting the Career Anxiety of Chinese university high-level soccer players, to construct a chain mediation model, and to provide intervention suggestions to alleviate the Career Anxiety of this ...
Yu-Juan Feng, Zhen-Yu Zhang, Wei Wang, Wen-Juan Zhang, Guang-Wei Che   +4 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Career exploration and its influence on the relationship between self-efficacy and career choice: The moderating role of social support

Heliyon
Career choice is a highly complex process. The growth in the number, nature, and overlap between occupations creates a more multifaceted career landscape, especially for young people.
Minh Pham, Bao Quoc Lam, Anh Tuan Ngoc Bui   +2 more
doaj   +1 more source

Impact of Generalist Physician Initiatives on Residency Selection [PDF]

, 2001
Objective:To compare the residency selection choices of students who experienced courses resulting from generalist physician initiatives to choices made by students prior to the implementation of those courses and to describe the characteristics of ...
Malloy MD, Michael H., Stroup-Benham PhD, Christine A.   +1 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Overconfidence and career choice [PDF]

, 2014
People self-assess their relative ability when making career choices. Thus, confidence in own abilities is likely an important factor for selection into various career paths.
Schulz, Jonathan F., Thöni, Christian
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Online career construction for a trauma survivor with career choice ambivalence

South African Journal of Higher Education
This article reports on the online administration of career construction counselling for a trauma survivor who sought help in resolving her career-choice ambivalence (uncertainty). The participant was purposively selected from a group of people attending
J. G. Maree
doaj   +1 more source

Career choices in academia [PDF]

, 2013
Based on a unique survey, we conduct a stated choice experiment to examine the determinants of career choice in academia. Both early and later stage researchers value a balance between teaching and research, appropriate salaries, working with high-quality peers and good availability of external grants.
Janger, Jürgen, Nowotny, Klaus
openaire   +4 more sources