Results 71 to 80 of about 15,240,876 (259)

Workforce needs of the career development sector in the UK [PDF]

, 2018
The research utilised an online survey circulated widely through the networks of both organisations. Responses were received from 59 employing organisations, representing the four countries in the UK.
Neary, S., Priestley, Peter
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Deconstructing barriers to support Japanese students in group discussion

The Asia Pacific Scholar, 2022
Kiyotaka Yasui, Maham Stanyon, Yoko Moroi, Shuntaro Aoki, Megumi Yasuda, Koji Otani , Yayoi Shikama   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Exploratory metabolomic profiling reveals metabolic alterations potentially associated with pain and blood pressure regulation in a high-sugar diet rat model

Scientific Reports
A high-sugar diet (HSD) is associated with various health issues, including metabolic dysfunction, inflammation, hypertension, and increased pain sensitivity.
Ting Li, Lanxin Zhang, Yan Wu, Congcong Sun, TongTong Wu, Eli Eliav, Qian Wang, Eli Sun, Yumei Feng Earley, Jin Xiao   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The effect of career-related teacher support on career development for technical students in China

, 2016
Career-related teacher support plays an important role in youths’ career development. Currently in the Chinese technical education context, inadequate attention has been paid to research on the effect of teacher support on career development.
Yuen, MT, Chen, G, Zhang, J
core  

UNO Website ACDC Academic and Career Development Center [PDF]

, 2016
We facilitate academic and career success and career development with resources and services for academic and career ...
Academic and Career Development Center, UNO
core   +1 more source