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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Annals of MedicineIntroduction This study intended to evaluate the medium-term effectiveness of a community-based medical education (CBME) program and to determine the program’s influence on the application rates of regional-quota students seeking to become residents in ...
Tsuneaki Kenzaka +5 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
UNO Website ACDC Academic and Career Development Center [PDF]
, 2016 We facilitate academic and career success and career development with resources and services for academic and career ...
Academic and Career Development Center, UNO
core +1 more source
Career Development as Freedom [PDF]
, 2023 This lecture explores the Capability Approach and its potential to provide a way of thinking about career development that links theory, practice, and policy.
Robertson, P.
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Career development learning in higher education: how authentic work experiences and opportunities for career exploration canincrease self-efficacy and inform career identity [PDF]
, 2015 A recent study suggests that enhancing career development is a key motivator for students entering university (Kandiko & Mawer, 2013). This article discusses the place of career development learning within the ‘employability’ agenda.
Benton, Paula
core
A case study of South Africa: Strengthening pathways from education to the world of work
African Journal of Career DevelopmentThe European Union (EU)-supported Education for Employability (E4E) Technical Assistance project in South Africa aimed to enhance youth employability by aligning education, training and employment systems.
Christopher J. Beukes +8 more
doaj +1 more source
Understanding the phases and objectives of the career development process in the context of successful career management [PDF]
Trendovi u Poslovanju, 2020 The basis of a quality organization consists of reliable employees who are satisfied with their work, ready to learn and progress, and thus continuously bring profit and progress to themselves and the organization.
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