Results 111 to 120 of about 2,020,641 (355)

Application of Immersive Virtual Reality in the Training of Future Teachers: Scope and Challenges

open access: yesVirtual Worlds
Introduction: The integration of Immersive Virtual Reality (IVR) into teacher education is a significant innovation that can enhance the learning and practical training of future teachers.
Carlos Arriagada-Hernández   +4 more
doaj   +1 more source

Lessons from Women Leaders: The Impact of Professional Development [PDF]

open access: yes, 2018
Professional development is learner-centered, where the responsibility to engage in further educational experiences belongs to the individual and is a critical way to prepare for career advancement.
Wegner, Jennifer
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Development and validation of career sustainability scale for mid-career employees

open access: yesFrontiers in Psychology
A sustainability perspective on careers builds a resilient career system by simultaneously considering individual’s current career needs and long-term career outcomes.
Suyeon Kim, Heesu Lee, Sungmi Jin
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Role of Smartphone Addiction as a Mediator between Psychological Resilience and Insomnia in Medical Students at a University

open access: yesPsychiatry and Clinical Psychopharmacology
Background: To explore the mediating effect of smartphone addiction between psychological resilience and insomnia among university students. Methods: This study included 581 clinical medical students from the Dalian Medical University, enrolled ...
Fan Li
doaj   +1 more source

Introduction to Information Technology Careers: Your Guide to Computer-Related Careers [PDF]

open access: yes, 2003
This handbook helps women learn the basics about career and education opportunities in information technology. The guide is for use by individual women, school counselors and other workforce development professionals to provide career and education ...

core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

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