Results 121 to 130 of about 376,224 (311)

The role of career feedback in the career development of young adults [PDF]

, 2016
Individuals shape their own lives and express their self-concepts in the world of work by continually setting career goals and taking career-related actions (Savickas, 2002).
Hood, M, Creed, PA, Hu, S
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Career Development Handbook [PDF]

Many guides to career development practice focus narrowly on specific aspects of career education and guidance, leaving new learners without a comprehensive overview. This brand-new handbook sets out to change that by combining practical insights, policy
Frigerio, G., Alexander, R., Hooley, T.
core  

Career Guidance, Health and Well-being [PDF]

, 2017
This is a brief article for practitioners in the Career Development Institute's magazine: Career Matters. It explores the links between work, health and well-being, and considers the implications for career development ...
Robertson, Peter
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Barriers and Associated Factors to Writing Case Reports Among Japanese General Medicine Physicians: A Cross‐Sectional Study of the Japan Primary Care Association Members

Journal of General and Family Medicine
Background Case reports are an important academic output for general medicine physicians; however, publication rates in Japan remain low, and barriers to preparing case reports have not been fully clarified.
Tsuneaki Kenzaka, Shinsuke Yahata, Naoya Mizutani, Ayako Kumabe, Ryo Fujiwara, Moe Kyotani, Koki Kosami, Hiroyuki Mori   +7 more
doaj   +1 more source

The Role of Smartphone Addiction as a Mediator between Psychological Resilience and Insomnia in Medical Students at a University

Psychiatry and Clinical Psychopharmacology
Background: To explore the mediating effect of smartphone addiction between psychological resilience and insomnia among university students. Methods: This study included 581 clinical medical students from the Dalian Medical University, enrolled ...
Fan Li
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Development of a brief measure of career development influences based on the Systems Theory Framework of Career Development [PDF]

, 2007
This paper documents the initial development and validation of a brief quantitative measure of career development influences based on the Systems Theory Framework of career development (McMahon & Patton, 1995; Patton & McMahon, 1997, 1999, 2006). Initial
Bridgstock, Ruth S.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source