Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
You don't know what's around the corner: A qualitative study of professional footballers in England facing career-transition [PDF]
Career transition in sport is a rapidly growing area within the field of sport psychology. Interest in this area has been fuelled by the need for an increased number of professional athletes seeking support and assistance during transition from sport ...
Brownrigg, Andrew +3 more
core
A Bibliometric Study on the Effectiveness of Career Interventions for Career Maturity
This study aims to determine the effectiveness of career interventions in enhancing career maturity and preparing individuals for the job market. By aligning career choices with personal interests and skills, this research identifies significant gaps in understanding their impact.
Aizuddin Ghazali +2 more
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Career decision ambivalence and career change ambivalence: A case study of two intertwined concepts [PDF]
The concept of ambivalence has received little attention within the field of vocational psychology. In this article, we distinguish between two types of ambivalence that may surface during the career counseling process: career decision ambivalence (i.e.,
Cardoso, Paulo Miguel +4 more
core +1 more source
Career Self-Management as a Key Factor for Career Wellbeing [PDF]
Career self-management (CSM) is an important factor for achieving career wellbeing and is becoming increasingly crucial in career environments characterized by higher volatility, uncertainty, complexity, and ambiguity. The objective of this chapter is to
Wilhelm, Francisco +3 more
core +1 more source
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A Strengths-Based Longitudinal Career Intervention for Junior Secondary School Students with Special Educational Needs: a Mixed-method Evaluation. [PDF]
Yuen M +8 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The perspectives of social cognitive career theory approach in current times
Danqi Wang, Xiping Liu, Haiyan Deng
doaj +1 more source

