Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Career self-management and vocational guidance: theory, practice and empirical contributions [PDF]
En este artículo se aborda y discute el concepto de gestión personal de la carrera y su importancia en términos de empleabilidad profesional en la vida adulta.
Rodríguez-Moreno, Maria Luísa +1 more
core
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The perspectives of social cognitive career theory approach in current times
Danqi Wang, Xiping Liu, Haiyan Deng
doaj +1 more source
A Strengths-Based Longitudinal Career Intervention for Junior Secondary School Students with Special Educational Needs: a Mixed-method Evaluation. [PDF]
Yuen M +8 more
europepmc +1 more source
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
The Impacts of Medical Career Day to Medical Students' Interest to Pursue a Career in Public Health
Background: Medical career day is one of the activities to introduce career options that exist and increase interest in a particular career. This study aims to determine the effect of material medical career day activities to increase the interest of ...
Rio Yus Ramadhani +2 more
doaj +1 more source
The Current Status of School Counseling Outcome Research [PDF]
Wendy McGannon has taken the lead in developing a review and analysis of The Current Status of School Counseling Outcome Research. Some basic information related to the NCLB mandates are reviewed in terms of how they impact the school counseling ...
Carey, Jay +2 more
core +1 more source
A systematic review of strategies to recruit and retain primary care doctors [PDF]
Background There is a workforce crisis in primary care. Previous research has looked at the reasons underlying recruitment and retention problems, but little research has looked at what works to improve recruitment and retention.
A Douglas +59 more
core +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source

