Results 71 to 80 of about 676,559 (307)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Career Guidance for Unaccompanied Young Migrants. A Report on an Italian Experience
Journal for Perspectives of Economic Political and Social Integration, 2020 Unaccompanied foreign minors are migrant children without their parents, relatives, or other adults. In Italy, especially in Sicily, an increasing number of young, non-European Union foreigners arrive daily in search of a new life and work opportunities.
Paola Magnano, Andrea Zammitti
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Promoting healthy transition from college to work market throughout seminars: the building of the therapeutic relationship [PDF]
, 2009 This communication presents a specialized preventive career intervention – the Career Self-Management Seminar (CSMS; Taveira et al., 2006 – forms A and B).
Loureiro, Nazaré +2 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Effect of Counseling in Self and Career Development to Enhance Students Awareness of Their Personal and Study Problems [PDF]
, 2008 Gifted students may insufficiently have insight of their problem-solving and lack of certain skills to solve their problems in various areas. Preliminary survey on students in l0th and 12th grade of acceleration program for gifted students reveals that,
Kartika, Aniva
core
Evaluation of the Legacy Careers Project [PDF]
, 2016 London Legacy Development ...
Dodd, Vanessa, Hooley, Tristram
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Interdisciplinary educational intervention to career groups
INFAD, 2019 Background: The quality of life of caregivers is conditioned by several factors: the context of the caregiver, the degree of dependency of the family member, the type of illness, the mediating elements (formal administration and informal support, family ...
Carmen García López +2 more
doaj +1 more source