Results 41 to 50 of about 1,116,810 (291)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Career advising in family medicine: a theoretical framework for structuring the medical student/faculty advisor interview

Medical Education Online, 2013
Background: There are unique challenges to recruiting students into the specialty of family medicine within academic medical centers. Methods: At Virginia Commonwealth University, we developed an advising framework to help students address institutional ...
Melissa Bradner, Steven H. Crossman, Allison A. Vanderbilt, Judy Gary, Paul Munson   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Career Adaptability and Resilience of Mental Health Service Users: The Role of Career Counseling

Behavioral Sciences, 2023
The employment rate of people who face severe mental health issues is extremely low, while the vast majority expresses their willingness to work. There are various obstacles that impede their work re-integration process.
Nikos Drosos, Antonis Korfiatis
doaj   +1 more source

A career in career - understanding what career looks like in the career development sector [PDF]

, 2017
There is little known about the careers workforce in the UK. This research focuses on developing a better understanding of who chooses to become a career development practitioner, their motivation, the transferable skills they bring with them and how ...
Neary, S., Hanson, Jill, Cotterill, Vicky   +2 more
core  

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Enhancing professionalism - progressing the career development sector [PDF]

, 2015
Much has changed in the career development sector since the launch of the Careers Profession Task Force report, ‘Towards a Strong Careers Profession’ in 2010.
Neary, Siobhan, Neary, S., Johnson, Claire   +2 more
core  

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Obstacles Faced By Female Doctors In Pursuing Their Careers.

JMMC, 2010
Objective: To determine the cultural and social hurdles faced by female doctors and to recognize the possibleobstacles in pursuing their careers.Subjects and Method:Study Design: Cross-sectionalPlace: Five hospitals in Karachi, viz. Jinnah Postgraduate Medical Centre, Civil Hospital, Aga Khan UniversityHospital, Ziauddin Medical University Hospital and
null Zulfiqar Ali Shaikh, null Ghulam Ali, null Zeenat Ayoob, null Husnain G. Ali, null Saba Saleem, null Tooba Fatima Chohan, null Fareeha Ali Khan, null Mehreen lqba, null Raabiya Fazal Dad, null Ruhma Ashraf, null Yusra Azhar   +10 more
openaire   +1 more source

Is an Apple an Orange? A Large Language Model Benchmark for Candidate Term Extraction and Subclass Decisions Against Upper Ontologies in Engineering and Materials Science

Advanced Engineering Materials, EarlyView.
Building machine‐readable vocabularies for materials science is slow, expert‐driven work. This study benchmarks 13 large language models on two of its first steps: finding candidate terms in engineering articles and deciding where they belong in a class hierarchy.
Thomas Bjarsch, Maximilian Holland, Klaus Drechsler, Johannes Schilp   +3 more
wiley   +1 more source