Results 71 to 80 of about 46,926 (265)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Campaigning for science and scientists
eLifeA Congressional Science & Technology policy fellow outlines some options available for responding to the blatant attacks on science and the scientific workforce in the US.
Adriana Bankston
doaj +1 more source
eLife, 2015 Reading and discussing classic papers can be an effective way of teaching graduate students how to learn the skills they will need for a career in research, as Indira M Raman explains.
Indira M Raman
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Navigating the path to a biomedical science career [PDF]
PLOS ONE, 2018 The number of biomedical PhD scientists undergoing training and graduating far exceeds the number of academic faculty positions and academic research jobs. This trend compels biomedical PhD scientists to increasingly seek career paths outside of academia.
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
International Journal of STEM Education, 2018 Background A sample of 1448 students in grades 7 and 9 was drawn from public schools in Atlantic Canada to explore students’ knowledge of science and mathematics requirements for science, technology, engineering, and mathematics (STEM) careers.
Karen A. Blotnicky +3 more
doaj +1 more source
Bringing "New Science? into Careers Research
M@n@gement, 2002 This paper reflects on the first author’s attempts to adapt traditional social science methods to her own purpose. The research involved developing a methodology to explore the subjective career, concerned with people’s internal, self-referential views of their unfolding career experiences. The paper describes a series of problems encountered along the
Parker, Polly, Arthur, Michael B.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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