Results 131 to 140 of about 484,284 (292)

Facilitating Expedited Drug Approval– the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, Accepted Article.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Pediatric Feeding Disorder: Consensus Definition and Conceptual Framework [PDF]

, 2019
Pediatric feeding disorders (PFDs) lack a universally accepted definition. Feeding disorders require comprehensive assessment and treatment of 4 closely related, complementary domains (medical, psychosocial, and feeding skill-based systems and associated
Browne, Joe, Cohen, Sherri S., de Camargo, Olaf Kraus, Delaney, Amy, Dodrill, Pamela, Feuling, Mary B., Gisel, Erika, Goday, Praveen S., Huh, Susanna Y., Kenzer, Amy, Kessler, Daniel B., Lukens, Colleen T., Noel, Richard J., Phalen, James A., Silverman, Alan   +14 more
core   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Fear of Cancer Recurrence and Associated Factors in Lymphoma Survivors and Their Family Caregivers: A Cross‐Sectional Study

Cancer Medicine
Background Fear of cancer recurrence (FCR) is a pervasive concern among lymphoma survivors and their family caregivers, influencing psychological and physical health. Given the substantial burden of FCR, identifying its predictors is crucial for targeted
Taha Koray Sahin, Ezgi Aysu Sahin, Hande Nur Gungor, Deniz Can Guven, Ibrahim Barista, Serkan Akin   +5 more
doaj   +1 more source

Nickel‐Catalyzed Twofold Conjunctive Coupling via Philicity‐Alternating Radical Relay

Advanced Science, EarlyView.
Herein, we disclose a nickel‐catalyzed twofold conjunctive coupling that enables a four‐component assembly involving an activated alkene, a 1,3‐enyne, and both alkyl and aryl halides. Multiple C–C bonds are selectively constructed through a philicity‐alternating radical relay and the selective radical capture by the nickel catalyst.
Ji Hwan Jeon, Da Hye Kim, Gun Ha Kim, Gyuhwan Sim, Jan‐Uwe Rohde, Byunghyuck Jung, Sangwon Seo, Sung You Hong   +7 more
wiley   +1 more source

Caregiving Experiences of Caregivers of Adolescents With Inflammatory Bowel Disease: A Qualitative Meta‐Synthesis

Nursing Open
Background Inflammatory Bowel Disease (IBD) is a chronic condition that significantly affects the physical and mental health of adolescents. Caregivers are crucial in the treatment process, offering both physical care and emotional support.
Huan Xu, Chao Wu, Changchang Chen, Bo Yan, Ning Zha, Kai Zhang, Fang Liu, Hongjuan Lang   +7 more
doaj   +1 more source

Pacinian Corpuscle‐Inspired Strain Conversion Enables Ultrasensitive, Linear, and Broad‐Range Piezoelectric Sensing for Cardiovascular Health Monitoring

Advanced Science, EarlyView.
A bioinspired piezoelectric sensor mimicking Pacinian corpuscles is developed to enable ultrasensitive and linear pressure sensing. A multilayer grooved architecture converts normal pressure into in‐plane strain, delivering high sensitivity, wide linear range, and efficient energy harvesting, enabling high‐fidelity wrist pulse monitoring and ...
Qi Yang, Zhongqian Song, Shengjie Liu, Yingming Ma, Weiyan Li, Huijun Kong, Cuiyu Liu, Yu Bao, Li Niu   +8 more
wiley   +1 more source

Latina Women in the United States: Child Care Preferences and Arrangements [PDF]

, 2017
Formal child care has been associated with myriad benefits for children, such as improvements in cognitive development and language skills. Immigrant children may derive unique benefits from formal child care, as research has also confirmed that center ...
Banik, Rumeli, Ph.D., Roubeni, Sonia, M.A., Satkowski, Laura, Ph.D.   +2 more
core   +1 more source