Results 71 to 80 of about 293,592 (310)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Northern Sea Route as a shipping route and an investment transport megaproject

Ученые записки Российской академии предпринимательства
Today the Northern Sea Route is the shortest maritime transport route that connects European countries and the countries of the Far East. One of the key advantages of transportation along the Northern Sea Route is saving time, for example, from Murmansk ...
A. M. Novozhilov
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Evaluation of Aeronautical Design Standard-33E Cargo Mission Requirements - Flight Tests with a CH-53G -

, 2006
Flight tests with a Sikorsky CH 53G cargo helicopter of the German Army were performed in Germany to evaluate the applicability and repeatability of the Aeronautical Design Standard (ADS)-33E-PRF cargo helicopter mission handling qualities requirements ...
Blanken, Chris L., Strecker, Gerhard, Höfinger, Marc   +2 more
core  

Turkish cargo strategies [PDF]

, 2017
Serdar Demir divided his speech to three sections as Turkish Airlines, Turkish cargo and Turkish cargo strategies at the 3rd airport. In the first section, he talked about general situation of Turkish Airlines.
Demir, S.
core  

Creating a reference database of cargo inspection X-ray images using high energy CT of cargo mock-ups

, 2016
International audienceCustoms continue to use a wide range of technology in protecting against terrorism and the movement of illicit trade and prohibited imports. The throughput of scanned vehicles and cargo increases and just keeps on growing. Therefore,
Ger Koomen, Marius Costin, Canonica, Andrea, Plamondon, Mathieu, Flisch, Alexander, Ulf Hassler, Wicher Visser, Hartmann, Stefan, Micha Slegt, Kolokytha, Selina, Hardmeier, Diana, Sukowski, Frank, Irene Dorion, Mathieu Plamondon, Luthi, Thomas, Vienne, Caroline, Thomas Luthi, Alexander Flisch, Hassler, Ulf, Slegt, Micha, Caroline Vienne, Stefan Hartmann, Schwaninger, Adrian, Selina Kolokytha, Costin, Marius, Rochat, Eric, Eric Rochat, Andrea Canonica, Frank Sukowski, Visser, Wicher, Dorion, Irene, Diana Hardmeier, Koomen, Ger, Adrian Schwaninger   +33 more
core   +1 more source

THE GROWING POTENTIAL OF EXTRACELLULAR VESICLE RESEARCH IN VETERINARY MEDICINE

Slovenian Veterinary Research
Extracellular vesicles (EVs) are small, information-rich subcellular structures that have attracted considerable attention in the scientific community.
Saša Koprivec
doaj   +1 more source

Information Technology as the Main Competence in the Design of the Strategic Planning of Logistics Platforms

Journal of Technology Management & Innovation, 2013
The creation of logistical support structures aims to help improve the performance of logistics along supply chains, a context where the Logistics Platforms have been gaining increasing prominence.
Leonardo Varella, Mirian Buss Gonçalves
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Visualization of protein-protein interactions in the secretory pathway of mammalian cells [PDF]

, 2006
An increasing number of human disorders are being linked to mutations in components of the secretory pathway. One example is combined blood coagulation factor V and VIII deficiency, an autosomal recessive disorder leading to hemophilia due to markedly ...
Nyfeler, Beat
core   +1 more source