Results 321 to 330 of about 162,227 (374)

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Biallelic TMEM126B Variants as a Novel Cause of Kidney Failure—Implications for Mitochondrial Genetic Testing in Nephrology

Clinical Genetics, Volume 109, Issue 1, Page 206-208, January 2026.
An adult with kidney failure had compound‐heterozygous TMEM126B variants causing mitochondrial complex I deficiency. This expands TMEM126B to mitochondrial nephropathy and supports including mitochondrial genes in renal genetic testing.
Zachary T. Sentell, Anthony C. T. Cheung, Felicia Russo, Chantal Bernard, Rita Suri, Andrey V. Cybulsky, Daniela Buhas, Thomas M. Kitzler   +7 more
wiley   +1 more source

Effect of L-Carnitine on Muscle Quality and Antioxidant Capacity of Hybrid Sheep at an Early Stage. [PDF]

Animals (Basel)
Qin X, Liu W, Xin J, Zhang Y, Zhang M, Liang W, Li J, Hu J.   +7 more
europepmc   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

Altered carnitine-acylcarnitine profiles in levothyroxine-treated congenital hypothyroid patients with fatigue: An LC-MS/MS-based study from Bangladesh. [PDF]

PLoS One
Begum MN, Sarker SK, Islam MT, Bhuyan GS, Mahtarin R, Patwary MH, Konika TK, Qadri SK, Ahmed T, Banu H, Sultana N, Rahat A, Shyamaly KJ, Bhuiyan TR, Hasan M, Hasanat MA, Sajib AA, Islam ABMMK, Mannoor K, Akhteruzzaman S, Qadri F.   +20 more
europepmc   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Journal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L. Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A. Williams, Patricia Rodriguez‐Rodriguez, Luana Naia   +12 more
wiley   +1 more source

Innovations in peritoneal dialysis fluid: biocompatible formulations and expanded therapeutic applications. [PDF]

Ren Fail
Xu Q, Zhou Z, Jin L, Liu C, Li P, Wang F, Zhang L, Fu P.   +7 more
europepmc   +1 more source

Serum acylcarnitines profile at ICU discharge to predict mid-term muscle outcomes: an exploratory study. [PDF]

Front Med (Lausanne)
Rousseau AF, Farnir F, Cavalier E, Luis G, Kellens I, Lambermont B, Boemer F.   +6 more
europepmc   +1 more source

Newborn screening for fatty acid oxidation disorders: epidemiological and genetic findings in Southeastern China. [PDF]

BMC Pediatr
Zhang S, Li X, Ye S, Song W, Chen H.
europepmc   +1 more source

Acute L-Carnitine Supplementation Does Not Improve CrossFit^® Performance: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. [PDF]

Nutrients
Devrim-Lanpir A, Velasco LS, Ramirez Lara FG, Ojeda Sanchez A, Kimble R, Zare R, Gunes FE, Knechtle B, Weiss K, Rosemann T, Heinrich K.   +10 more
europepmc   +1 more source