L-Carnitine and Pentoxifylline Supplementation Improves Sperm Viability and Motility at Low Temperature [PDF]
International Journal of Fertility and Sterility, 2023 Background: In infertility clinics, preserving high-quality spermatozoa for a long time is a necessity. Pentoxifylline (PT) and L-carnitine (LC) are effective in improving sperm motility as well as protecting the sperm membrane.
Zohre Nateghian +4 more
doaj +1 more source
A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]
, 2018 Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev +51 more
core +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Secondary Carnitine Deficiency in Dialysis Patients: Shall We Supplement It? [PDF]
European Medical Journal Nephrology, 2016 Carnitine, essential for fatty acid β-oxidation, is obtained from diet and through de novo biosynthesis. The organic cation/carnitine transporter 2 (OCTN2) facilitates carnitine cellular transport and kidney resorption.
Ronald J.A. Wanders +3 more
doaj
The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment
Physiological Reports, 2021 Leg cramping is a common side effect of hemodialysis, and this is frequently treated by the administration of carnitine, but this is not effective in every patient. Alkalosis is a key component of the etiology of leg cramping during hemodialysis sessions.
Akira Takahashi
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background The molecular mechanisms involved in atrial fibrillation are not well known. We used plasma metabolomics to investigate if we could identify novel biomarkers and pathophysiological pathways of incident atrial fibrillation.
Lars Lind +7 more
doaj +1 more source
Usefulness of Carnitine Supplementation for the Complications of Liver Cirrhosis
Nutrients, 2020 Carnitine is a vitamin-like substance that regulates lipid metabolism and energy production. Carnitine homeostasis is mainly regulated by dietary intake and biosynthesis in the organs, including the skeletal muscle and the liver.
T. Hanai +5 more
semanticscholar +1 more source
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Valproic-induced Fanconi syndrome: Clinical features, risk factors, diagnosis and management
Frontiers in Medicine, 2022 ObjectiveAlthough Fanconi syndrome (FS) induced by valproate (VPA) has occasionally been reported, the detailed clinical features of the disease remain unclear.
Chunjiang Wang +4 more
doaj +1 more source
The carnitine system and cancer metabolic plasticity
Cell Death and Disease, 2018 Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions.
M. Melone +5 more
semanticscholar +1 more source