Results 81 to 90 of about 133,759 (327)

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis [PDF]

Journal of Medical Biochemistry, 2015
Background: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower ...
Sahebkar Amirhossein
doaj  

Effects of Exercise Training on Renal Carnitine Biosynthesis and Uptake in the High-Fat and High-Sugar-Fed Mouse

Molecules, 2020
(1) Background: Diet-induced obesity inhibits hepatic carnitine biosynthesis. Herein, the effects of high-fat (HF) and high-sugar (HFHS) feeding and exercise training (ET) on renal carnitine biosynthesis and uptake were determined.
Aman Upadhyay, Layla Al-Nakkash, Tom L. Broderick   +2 more
doaj   +1 more source

Genes involved in carnitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation [PDF]

, 2013
BACKGROUND:Convincing evidence exist that carnitine synthesis and uptake of carnitine into cells is regulated by peroxisome proliferator-activated receptor alpha (PPARA), a transcription factor which is physiologically activated during fasting or energy ...
Becker, Sabrina, Eder, Klaus, Erhardt, Georg, Hillen, Sonja, Most, Erika, Reiner, Gerald, Ringseis, Robert, Rosenbaum, Susann   +7 more
core   +2 more sources

Impaired healing following implant placement surgery: A case report of a modern‐day manifestation of scurvy

Clinical Advances in Periodontics, EarlyView.
Abstract Background Delayed wound healing following implant placement surgery is an uncommon complication, usually attributed to systemic (smoking and alcohol), local (severely inflamed tissues), or technical (poor suturing) factors. However, delayed wound healing after implant placement caused by severe hypovitaminosis C has not been previously ...
Gregor‐Georg Zafiropoulos, Gerald Kolb, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Effects of Dietary Supplements of Pediasure and Carnitine on the Anthropometric Indicesin Children with Acute Lymphoblastic Leukemia under Chemotherapy, in Afzalipour Hospital, Kerman,Iran [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & Aims: Malnutrition is a common complication of cancer and cancer treatment in children. This occurs in 50% of these patients. Dietary supplements may have a significant effect on the response to treatment,survival, recurrence, mortality, and
A Naderi, F Doustan, A Shahabi Nejad, A Dehghani, M Hayatbakhsh Abbasi   +4 more
doaj  

The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters [PDF]

, 2014
The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner
Agrimi, G., Cirigliano, A., Di Noia, M. A., Iacobazzi, V., Palmieri, Ferdinando, Rinaldi, T., Todisco, S.   +6 more
core   +2 more sources

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

The Effect of Chronic Intake of L-carnitine L-tartrate on Lipid Metabolism during Aerobic Exercise [PDF]

Journal of Kerman University of Medical Sciences, 2010
Background & Aims: Despite 20 years of research, there is no compelling evidence about the effect of carnitine supplementation on improving physical performance in healthy subjects.
M Ezedi, F Nazem, A Zarifian, A Eghdami, D KHorshidi   +4 more
doaj