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Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source

Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. METHODS Longitudinal MRI study, including 80 DS adults and 53 euploid controls. WMH were segmented on serial FLAIR using a longitudinal pipeline.
Alejandra O. Morcillo‐Nieto +24 more
wiley +1 more source

Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma (ARIA)‐EAACI 2024–2025 Guidelines: From Evidence‐to‐Decision Frameworks to Digitalised Shared Decision‐Making Algorithms

Allergy, Volume 81, Issue 2, Page 427-453, February 2026.
The Allergic Rhinitis and its Impact on Asthma (ARIA) group is working on the 2024–2025 update of its guidelines for the management of allergic rhinitis (ARIA 2024–2025). The ARIA 2024–2025‐EAACI guidelines will follow GRADE methodology and will incorporate evidence from different sources, including systematic reviews and meta‐analyses, mHealth data ...
Jean Bousquet +230 more
wiley +1 more source

On‐Chip Perovskite Coolers

Advanced Materials Technologies, Volume 11, Issue 1, 8 January 2026.
Scaling of 3D‐integrated electronics exacerbates thermal bottlenecks, motivating solid‐state on‐chip cooling beyond convection and immersion. This perspective reviews optical refrigeration, electroluminescent cooling, and thermoelectrics for localized, vibration‐free heat removal.
Huilong Liu +2 more
wiley +1 more source

Future Perspective On Materials, Electrochemistry, and Cell Concepts for Redox‐Mediated CO2 Direct Air Capture Scenarios

ChemistryEurope, Volume 4, Issue 1, January 2026.
Direct air capture (DAC) of carbon dioxide (CO2) emerges as a key strategy for climate crisis mitigation. Redox‐mediated electrochemical carbon capture offers a promising route for energy‐efficient DAC. This perspective discusses recent advances in the field, highlighting key challenges, such as oxygen interference at low CO2 concentrations, and ...
Tilmann J. Neubert, Martin Oschatz
wiley +1 more source

Constructing Hölder maps to Carnot groups

Journal of the American Mathematical Society
In this paper, we construct Hölder maps to Carnot groups equipped with a Carnot metric, especially the first Heisenberg group H \mathbb {H} . Pansu and Gromov [Carnot-Carathéodory spaces seen from within, Birkhäuser, Basel, 1996] observed that any surface embedded in H \mathbb {H} has Hausdorff
Wenger, Stefan, Young, Robert
openaire +3 more sources

Conformal maps of Carnot groups

Annales Academiae Scientiarum Fennicae Mathematica, 2015
If f is a conformal mapping defined on a connected open subset of a Carnot group G, then either f is the composition of a translation, a dilation and an isometry, or G is the nilpotent Iwasawa component of a real rank 1 simple Lie group S, and f arises from the action of S on G, viewed as an open subset of S/P, where P is a parabolic subgroup of G and ...
Cowling, MG, Ottazzi, A
openaire +5 more sources

Development of New Benzo[b]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists

ChemMedChem, Volume 21, Issue 1, January 2026.
A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin +10 more
wiley +1 more source

Large sets at infinity and Maximum Principle on unbounded domains for a class of sub-elliptic operators

Bruno Pini Mathematical Analysis Seminar, 2019
Maximum Principles on unbounded domains play a crucial role in several problems related to linear second-order PDEs of elliptic and parabolic type. In the present notes, based on a joint work with prof. E.
Stefano Biagi
doaj +1 more source

A Cornucopia of Carnot groups in Low Dimensions [PDF]

, 2020
Enrico Le Donne, Francesca Tripaldi
openalex +1 more source

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