Results 71 to 80 of about 250,893 (267)

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Carotid artery surgery: back to the future Cirurgia de artéria carótida: de volta para o futuro

Jornal Vascular Brasileiro, 2011
In this study we performed 548 carotid revascularizations between 2006 and 2008 at the Department of Vascular Surgery of the A.Z. Sint-Blasius, Dendermonde, Belgium - a high-volume experienced center for carotid artery stenting (CAS). In 2006, our 30-day
Marc Bosiers, Gustavo Henrique Dumont Kleinsorge, Deloose Koen, Túlio Pinho Navarro   +3 more
doaj   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Early Carotid Structural and Functional Changes Associated With Elevated Blood Pressure in Children: A Multimodal Ultrasound Study

The Journal of Clinical Hypertension
Childhood hypertension is closely associated with cardiovascular disease in adulthood, and the carotid artery is one of the principal target organs affected by elevated blood pressure (BP).
Hui Wang, Yuanyuan Sheng, Xueyuan Lin, Ying Guo, Miaoru Yu, Youping Wang, Jie You, Jinfeng Xu, Yingying Liu   +8 more
doaj   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

STUDIES OF CAROTID BODY AND CAROTID SINUS: FINE STRUCTURE OF CAROTID BODY

Nihon Naika Gakkai Zasshi, 1966
古くから頚動脈洞反射にかんする研究は多く, 総頚動脈分岐部には, 圧受容体と化学受容体の存在することは多くの生理学者が認めるものである. これらにかんして, イヌを用いて, 頚動脈洞を刺激し, その血中カテコールアミン体の変動を認め, さらに, 動脈血中の化学成分の変化によつて起こる呼吸反射をみとめ, 先人の業績を確認しながら, 組織像を追究した. ことに, 電顕像および組織化学的方法によつても, 頚動脈体は, 腺でも単なる血管糸球でもなく, 傍神経節でもなく, クローム親和性細胞も認められず, いわゆる頚動脈体と呼称されるのにふさわしい臓器であることを認め, さらに, 頚動脈洞壁の微細構造と比較検討し, 本小体が化学受容体とされて当然のことと結語した.
openaire   +3 more sources

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

The Relationship of Carotid Intima-Media Thickness with Serum Calcium, Phosphorus, and Vitamin D [PDF]

Journal of Kerman University of Medical Sciences
Background: The potential predictive role of deficiencies in certain elements on the increase in carotid intima-media thickness (CIMT), and consequently on the formation of atherosclerotic plaques, remains an important question.
Ahmad Enhesari, Parya Soltaninejad, Ahmad Naghibzadeh Tahami, Zohreh Safi, Hosein Gozashti   +4 more
doaj   +1 more source