Results 61 to 70 of about 422,931 (314)

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Bradykinin/bradykinin 1 receptor promotes brain microvascular endothelial cell permeability and proinflammatory cytokine release by downregulating Wnt3a

Journal of Biochemical and Molecular Toxicology, Volume 36, Issue 12, December 2022., 2022
Abstract Stroke is a life‐threatening disease with limited therapeutic options. Damage to the blood–brain barrier (BBB) is the key pathological feature of ischemic stroke. This study explored the role of the bradykinin (BK)/bradykinin 1 receptor (B1R) and its mechanism of action in the BBB.
Linqiang Huang, Mengting Liu, Wenqiang Jiang, Hongguang Ding, Yongli Han, Miaoyun Wen, Ya Li, Xiaoyu Liu, Hongke Zeng   +8 more
wiley   +1 more source

The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators.

New England Journal of Medicine, 2000
BACKGROUND The causes of stroke in patients with asymptomatic carotid-artery stenosis have not been carefully studied. Information about causes might influence decisions about the use of carotid endarterectomy in such patients.
D. Inzitari, M. Eliasziw, P. Gates, B. Sharpe, R. Chan, H. Meldrum, H. Barnett   +6 more
semanticscholar   +1 more source

Automatic Diagnosis of Carotid Atherosclerosis Using a Portable Freehand 3D Ultrasound Imaging System [PDF]

arXiv, 2023
The objective of this study is to develop a deep-learning based detection and diagnosis technique for carotid atherosclerosis using a portable freehand 3D ultrasound (US) imaging system. A total of 127 3D carotid artery scans were acquired using a portable 3D US system which consisted of a handheld US scanner and an electromagnetic tracking system. A U-
arxiv  

Computational hemodynamics in arteries with the one-dimensional augmented fluid-structure interaction system: viscoelastic parameters estimation and comparison with in-vivo data [PDF]

J. Biomech. 100 (2020) 109595, 2019
Mathematical models are widely recognized as a valuable tool for cardiovascular diagnosis and the study of circulatory diseases, especially to obtain data that require otherwise invasive measurements. To correctly simulate body hemodynamics, the viscoelastic properties of vessel walls are a key aspect to be taken into account as they play an essential ...
arxiv   +1 more source

Giant cell arteritis as a cause of extracranial internal carotid artery aneurysm: a case report

Journal of Medical Case Reports
Background This report presents the management of patient with extracranial internal carotid artery pseudoaneurysm due to giant cell arteritis. Case presentation Left internal carotid artery pseudoaneurysm was diagnosed in a 57-year-old Ukrainian woman ...
Ihor Kobza, Yuliia Mota, Volodymyr Vovk
doaj   +1 more source

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Advanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du, Muhammad Rafiq, Hui Yuan, Xiangmin Li, Sheng Wang, Jun Wu, Jinfeng Wei, Ren‐Ke Li, Huiming Guo, Burton B Yang   +9 more
wiley   +1 more source

Comparison of 2D and 4D Flow MRI in Neonates Without General Anesthesia

Journal of Magnetic Resonance Imaging, Volume 57, Issue 1, Page 71-82, January 2023., 2023
Background Neonates with critical congenital heart disease require early intervention. Four‐dimensional (4D) flow may facilitate surgical planning and improve outcome, but accuracy and precision in neonates are unknown. Purpose To 1) validate two‐dimensional (2D) and 4D flow MRI in a phantom and investigate the effect of spatial and temporal resolution;
Pia Sjöberg, Erik Hedström, Katrin Fricke, Petter Frieberg, Constance G Weismann, Petru Liuba, Marcus Carlsson, Johannes Töger   +7 more
wiley   +1 more source

Carotid Artery Remodeling Is Segment Specific: An In Vivo Study by Vessel Wall Magnetic Resonance Imaging

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
Objective— Early atherosclerosis is often undetected due in part to compensatory enlargement of the outer wall, termed positive remodeling. Variations in hemodynamic conditions and clinical factors influence the patterns of remodeling. The carotid artery
H. Watase, Jie Sun, D. Hippe, N. Balu, Fei-yu Li, Xihai Zhao, V. Mani, Z. Fayad, V. Fuster, T. Hatsukami, C. Yuan   +10 more
semanticscholar   +1 more source

Neck dissection complicated with congenital internal carotid artery hypoplasia: A case report

Otolaryngology Case Reports, 2023
Preoperative diagnosis of the presence of anomalies or abnormalities of the cervical vessels is important to safely perform neck dissection in patients with head and neck cancer.
Takayuki Imai, Ayako Nakanome, Sinkichi Morita, Kazue Ito, Takahiro Goto, Yoji Yamashita, Yukinori Asada   +6 more
doaj