Results 91 to 100 of about 761,768 (392)

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Carotid artery stenting: an update [PDF]

, 2017
In patients with carotid disease, the purpose of carotid artery revascularization is stroke prevention. For >50 years, carotid endarterectomy has been considered the standard treatment for severe asymptomatic and symptomatic carotid stenoses.
Castriota, Fausto, Cremonesi, Alberto, Macdonald, Sumaira, Roffi, Marco, Secco, Gioel Gabrio   +4 more
core  

T Cell Activation and Senescence Predict Subclinical Carotid Artery Disease in HIV-Infected Women

Journal of Infectious Diseases, 2011
Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease ...
Robert C. Kaplan, E. Sinclair, A. L. Landay, N. Lurain, A. Sharrett, S. Gange, X. Xue, P. Hunt, R. Karim, David M. Kern, H. Hodis, S. Deeks   +11 more
semanticscholar   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Fully automated segmentation and tracking of the intima media thickness in ultrasound video sequences of the common carotid artery [PDF]

, 2013
—The robust identification and measurement of the intima media thickness (IMT) has a high clinical relevance because it represents one of the most precise predictors used in the assessment of potential future cardiovascular events.
A. Stanton, Alice Stanton, Alice Stanton, Alice Stanton, Alice Stanton, C. Duffy, Caoimhe Duffy, Caoimhe Duffy, Caoimhe Duffy, Caoimhe Duffy, D. E. Ilea, Dana E. Ilea, Dana E. Ilea, Dana E. Ilea, Dana E. Ilea, L. Kavanagh, Liam Kavanagh, Liam Kavanagh, Liam Kavanagh, Liam Kavanagh, P. F. Whelan, Paul F. Whelan, Paul F. Whelan, Paul F. Whelan, Paul F. Whelan   +24 more
core   +2 more sources

The Impact of Surgery Resident Participation on the Outcome of Carotid Endarterectomy [PDF]

, 2020
Introduction. The purpose of this study was to determine whether the in-hospital stroke rate plus deaths (SD) was adversely impacted by the participation of surgery residents during carotid endarterectomy. Methods.
Ammar, Alex
core   +2 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

The relative contributions of aortic and carotid artery stiffness to CeVD and cognition

Cerebral Circulation - Cognition and Behavior
Introduction: The relative contributions of aortic and carotid artery stiffness on cognitive impairment and dementia remain unknown. We examined the associations of aortic and carotid artery stiffness with cerebrovascular disease markers, cognition, and ...
Caroline Robert, Lieng-Hsi Ling, Eugene Tan, Narayanaswamy Venketasubramanian, Shir Lynn Lim, Lingli Gong, Josephine Berboso, Arthur Mark Richards, Christopher Chen, Chuen Seng Tan, Saima Hilal   +10 more
doaj   +1 more source

Ruptured Aneurysm of Extracranial Carotid Artery

Journal of Nepal Medical Association, 2008
Aneurysm of extracranial carotid artery is an uncommon clinical disease and that presenting as a ruptured aneurysm is extremely rare. This entity represents a challenge to treatment strategy.
Uttam Krishna Shrestha
doaj   +1 more source

Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. [PDF]

, 2014
BackgroundIndividuals with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease, partly due to systemic inflammation and endothelial dysfunction.
Del Puerto, Gus, Ganz, Peter, Graf, Jonathan, Grunfeld, Carl, Hsue, Priscilla Y, Imboden, John, Nitta, Elaine, Scherzer, Rebecca, Schnell Heringer, Amanda, Shigenaga, Judy, Wu, Yuaner   +10 more
core   +2 more sources