Results 51 to 60 of about 5,333,057 (253)
Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil +9 morewiley +1 more sourceRANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies. [PDF]
, 2011 The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be Hilma Holm, Poschen Ulrike, Panos Deloukas, Assimes, Themistocles L., Karakas, Mahir, Mahir Karakas, Erdmann, Jeanette, Moll, F.L., Robert Roberts, Illig, T., Samani, Nilesh J, Sekar Kathiresan, Muredach P Reilly, Koenig Wolfgang, Dominique P. V. de Kleijn, Herder, C., Thorand, Barbara, Illig Thomas, Preuss Michael, Pasterkamp, Gerard, Moll Frans L., null null, Ruth McPherson, König, Inke R, Poschen, Ulrike, Samani, Nilesh J., Karakas, M., Thorgeirsson, Gudmundur, de Kleijn Dominique P. V., Preuss, M, Frans L Moll, Alexandre F R Stewart, Meisinger Christa, Koenig, W., Holm, Hilma, de Kleijn, Dominique P. V., CARDIoGRAM Consortium, König, Inke R., Ulrike Poschen, Moll, Frans L, Roberts, Robert, Peeters, Wouter, Koenig, Wolfgang, Karakas Mahir, Müller-Nurasyid, Martina, Jeanette Erdmann, Wouter Peeters, Thorand Barbara, Meisinger, Christa, Herder Christian, Klopp, Norman, Roden, M., Herder, Christian, Moll, Frans L., Roden, Michael, Stewart, Alexandre FR, Gerard Pasterkamp, Heribert Schunkert, Martina Müller-Nurasyid, Müller-Nurasyid, M., Pasterkamp Gerard, Jens Baumert, Roden Michael, Klopp, N., McPherson, Ruth, Reilly, Muredach P, Inke R König, Deloukas, Panos, Schunkert, Heribert, Dominique P V de Kleijn, Kathiresan, Sekar, Wolfgang Koenig, Barbara Thorand, CARDIoGRAM Consortium (Illig, T. ; Wichmann, H.-E. ; Döring, A. ; Peters, A. ; Meitinger, T. ; Klopp, N. ; Meisinger, C.), Müller-Nurasyid Martina, Michael Preuss, Poschen, U., Preuss, Michael, Peeters, W., Illig, Thomas, Baumert, Jens, Reilly, Muredach P., Frans L. Moll, Christian Herder, Thomas Illig, Christa Meisinger, Stewart, Alexandre F. R., Klopp Norman, Meisinger, C., Assimes, Themistocles L, Peeters Wouter, de Kleijn, Dominique PV, Baumert Jens, de Kleijn, D.P., Stewart, Alexandre F R, de Kleijn, Dominique P V, Michael Roden, Themistocles L Assimes, Nilesh J Samani, Norman Klopp, Baumert, J.J., Thorand, B., Pasterkamp, G., Preuss, M., Schunkert, H., Kathiresan, S., Roberts, R., Erdmann, J., König, I.R., Deloukas, P., Assimes, T.L., Samani, N.J., Stewart, A.F., Baumert, J., Holm, H., McPherson, R., Reilly, M.P., Rice, K. (Kenneth), Meisinger, C. (Christa), Duijn, C.M. (Cornelia) van, Sinning, Christoph, Stewart, A.F.R. (Alexandre), Schillert, A. (Arne), Siscovick, D.S. (David), Go, Alan, Quertermous, T. (Thomas), Morrison, A.C. (Alanna), Linsel-Nitschke, P. (Patrick), Fortmann, S.P. (Stephen), Hengstenberg, Christian, Karakas M., Laaksonen, R. (Reijo), Whitteman, J. (Jaqueline), Grammer, T.B. (Tanja), Illig T., Nicaud, V., McPherson R., Peters, A. (Annette), Scharnagl, H. (Hubert), Waksman, R. (Ron), Ramachandran, V.S. (Vasan), Braund, P.S. (Peter), Moll F.L., Wright, B.J. (Benjamin), Chen, L. (Li), Blankenberg, Stefan, Samani N.J., Bis, J.C. (Joshua), Stark, K. (Klaus), Willenborg, C. (Christina), Blankenberg, S. (Stefan), Thorleifsson, G. (Gudmar), Bruse, P. (Petra), Laaksonen, Reijo, Stojakovic, T. (Tatjana), Boerwinkle, Eric, Zeller, Tanja, Dandona, S. (Sonny), Perret, C. (Claire), Meinitzer, A. (Andreas), Nelson, C.P. (Christopher P.), Barbalic, M. (maja), Wichmann, H.E. (Heinz Erich), Poschen U., Rotter, J.I. (Jerome), Illig, T. (Thomas), Tang, Hua, Folsom, A.R. (Aaron), Harris, T.B. (Tamara), Pichard, A.D., Waterworth, D. (Dawn), Wild, P.S. (Philipp), Andersen, K.K. (Karl), Burnett, M.S., Knouff, C.W. (Christopher), Li, Mingyao, Cupples, L.A. (Adrienne), Chen, I.Y.-D. (Ida Yii-Der), Voight, Benjamin F., Munzel, T. (Thomas), Preuss M., Heckbert, S.R. (Susan), Risch, N., Demissie-Banjaw, S. (Serkalem), Erdmann, J. (Jeanette), König, I.R. (Inke), Uitterlinden, Andre; id_orcid, Stewart, Alexandre F.R., Reilly M.P., Hlatky, Mark, Sidney, Steven, Klopp N., Hlatky, M.A. (Mark), Ziegler, A. (Andreas), Smith, N.L. (Nicholas), Rupprecht, H.J., Guiducci, C. (Candace), Stewart A.F., Schwartz, S.M. (Stephen), Wild, Philipp, Lindsay, J.M. (Joseph), van Duijn, Cornelia, Knowles, Joshua, Bickel, H. (Horst), Gretarsdottir, S. (Solveig), Wells, G.A. (George), Zeller, T. (Tanja), Zwart, J-A. (John-Anker), Tomaschitz, A. (Andreas), Hall, Alistair, Halperin, E. (Eran), Schnabel, Renate, Peeters W., Fortmann, Stephen, Winkler, K. (Karl), Cambien, F. (François), Hoffmann, M.M. (Michael), Altshuler, D. (David), Epstein, S.E. (Stephen), Thorsteinsdottir, Unnur, Levy, D. (Daniel), Preuss, M. (Michael), Roberts R., Koenig, W. (Wolfgang), Iribarren, Carlos, M乴ler-Nurasyid M., Koenig W., Hakonarson, H. (Hakon), Boerwinkle, E.A. (Eric), Kent, K.M. (Kenneth), Thompson, J.R. (John), Elosua, R. (Roberto), Lackner, K.J. (Karl), Wagner, A.K. (Arnika), Risch, Neil, Nahrstedt, J. (Janja), Renner, W. (Wilfried), Gudnason, V. (Vilmundur), Hengstenberg, C. (Christian), Walker, M.C. (Max), Cupples, L. Adrienne, Chen, Li, Reilly, M.P. (Muredach), Myers, Richard, McPherson, R. (Ruth), Qu, L. (Liming), Thompson, John R., Kong, A. (Augustine), Rader, D.J. (Daniel), Peltonen, L. (Leena Johanna), Schnabel, R.B. (Renate), Myers, R.H. (Richard), Doering, A. (Angela), Ball, S.G. (Stephen), Uitterlinden, A.G. (André), Wells, George A., Dobnig, H. (Harald), Absher, Devin, Dehghan, A. (Abbas), Hofman, A. (Albert), O'Donnell, C.J. (Christopher), Devaney, J. (Joseph), Quertermous, Thomas, Voight, B.F. (Benjamin), Assimes T.L., Roden M., de Kleijn D.P., Medack, A. (Anja), Sidney, S. (Steven), Schunkert H., Kleber, M. (Martina), Holm H., Jarinova, O. (Olga), Erdmann J., Thorgeirsson, G. (Gudmundur), Dehghan, Abbas, Hall, A. (Anne), Moll, F.L. (Frans), Balmforth, A.J. (Anthony), Mooser, V. (Vincent), März, W. (Winfried), Gabriel, S.B. (Stacey), Glazer, N.L. (Nicole), Roberts, R. (Robert), Thorleifsson, Gudmar, Großhennig, A. (Anika), Ziegler, Andreas, Meisinger C., Tiret, L. (Laurence), Salomaa, V. (Veikko), Melander, O. (Olle), Thorsteinsdottir, U. (Unnur), Matthai, W. (William), Samani, N.J. (Nilesh), Aherrahrou, Z. (Zouhair), Holm, H. (Hilma), Schunkert, H. (Heribert), Psaty, B.M. (Bruce), Thorand B., Tang, H. (Hui), Taylor, K.D. (Kent), Kathiresan S., Lumley, T. (Thomas), Kathiresan, S. (Sekar), Schreiber, S. (Stefan), Knowles, J.W. (Joshua), Sinning, C. (Christoph), Smith, A.V. (Davey), Li, M. (Mingyao), Hofman, Albert, Fischer, M. (Marcus), Deloukas P., Musunuru, K. (Kiran), Böhm, B., Lieb, W. (Wolfgang), Schillert, Arne, Baumert J., Proust, C. (Carole), Musunuru, Kiran, Klopp, N. (Norman), Winkelmann, B., Iribarren, C. (Carlos), Meitinger, T. (Thomas), Halperin, Eran, Go, A.T.J.I. (Attie), Herder C., Pilz, D.T. (Daniela), Loley, C. (Christina), Deloukas, P. (Panagiotis), Satler, L.F., Marciante, K. (Kristin), Gulcher, J.R. (Jeffrey), Pasterkamp G., Burtt, N.P. (Noël), Wilensky, A. (Asaf), K?nig I.R., Lackner, Karl, Volcik, K.A. (Kelly) +337 morecore +2 more sourcesMicrovascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study
Arthritis Care &Research, EarlyView.Objective
Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone +13 morewiley +1 more sourceS-Nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty [PDF]
, 2002 Background: The major complication of carotid angioplasty is embolic stroke, which may occur after balloon inflation and deflation or in the early postintervention period.Clifton, A., Markus, H.S., Martin, J.F., Kaposzta, Z., Molloy, J. +4 morecore Rheumatoid arthritis, frailty, and outcomes of surgical hospitalizations: A national population‐based analysis
Arthritis Care &Research, Accepted Article.OBJECTIVE
Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health outcomes after elective non‐cardiac surgery. METHODS
We conducted a cross‐sectional study using the National Inpatient Sample (2018 to 2020), including ...Ali Yazdanyar, Joshua Baker, Katherine D Wysham, Mohammed Yousufuddin, Farah Acher Kaiksow, Michael M. Ward +5 morewiley +1 more source
