Results 111 to 120 of about 697,026 (348)

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Improving Computer-Aided Medical Diagnosis Using Generative Adversarial Networks for Carotid Artery Ultrasound Image Data Augmentation and Classification

Journal of Electrical Engineering and Computer
Cardiovascular diseases are a leading cause of death globally, making early detection of atherosclerosis critical for prevention. Carotid artery ultrasound imaging is a common diagnostic tool; however, the limited availability of labelled medical images ...
Ricardo Fitas, João Gonçalves
doaj   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis

Lipids in Health and Disease, 2012
Background We analyzed the causal relationship between LDL susceptibility to oxidation and the development of new carotid artery atherosclerosis over a period of 5 years.
Aoki Toshinari, Abe Tsueko, Yamada Eiji, Matsuto Takayuki, Okada Masahiko   +4 more
doaj   +1 more source

A smart headband for multimodal physiological monitoring in human exercises

Advanced Science, EarlyView.
A novel smart headband incorporating a thermal‐sensation‐based electronic skin is presented for continuous and accurate multimodal physiological monitoring, including pulse waveforms, total metabolic energy expenditure, heart rate, and forehead temperature, across both static and dynamic daily activities.
Shiqiang Liu, Guanxing Chen, Jingyi Peng, Shuo Tian, Qian Mao, Caise Wei, Jinfeng Yuan, Rong Zhu   +7 more
wiley   +1 more source

Metagenomic Analysis of Bacterial Microflora in Dental and Atherosclerotic Plaques of Patients With Internal Carotid Artery Stenosis

Clinical Medicine Insights: Cardiology
Background: Internal carotid artery stenosis is primarily attributed to atherosclerosis in the carotid artery bifurcation. Previous studies have detected oral bacteria in atherosclerotic lesions, suggesting an association between oral bacteria and ...
Ayako Sato, Shintaro Arai, Kenji Sumi, Haruka Fukamachi, Satoko Miyake, Manami Ozawa, Mie Myers, Yasubumi Maruoka, Katsuyoshi Shimizu, Tohru Mizutani, Hirotaka Kuwata   +10 more
doaj   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

The structural properties of carotid arteries in carotid artery diseases - a retrospective computed tomography angiography study. [PDF]

Pol J Radiol, 2020
Özdemir Hİ.
europepmc   +1 more source

Smart Flexible Tactile Sensors: Recent Progress in Device Designs, Intelligent Algorithms, and Multidisciplinary Applications

Advanced Intelligent Discovery, EarlyView.
Flexible tactile sensors have considerable potential for broad application in healthcare monitoring, human–machine interfaces, and bioinspired robotics. This review explores recent progress in device design, performance optimization, and intelligent applications. It highlights how AI algorithms enhance environmental adaptability and perception accuracy
Siyuan Wang, Ming Dong, Rongrong Bao, Caofeng Pan   +3 more
wiley   +1 more source

Sex-Related Differences in Early In-Hospital Outcome (Technical Success and Complications) of Carotid Artery Stenting and Risk Factors of Carotid Artery Stenosis

Diseases
Background/Objectives: Stroke and arteriosclerotic diseases remain the main challenge for global healthcare. Carotid artery procedures aim to restore blood flow through the carotid arteries to prevent embolic events.
Kinga Natalia Dudzińska, Paweł Muszyński, Joanna Kruszyńska, Konrad Bagiński, Maciej Kowalczuk, Konrad Nowak, Anna Tomaszuk-Kazberuk, Paweł Kralisz, Sławomir Dobrzycki, Marcin Kożuch   +9 more
doaj   +1 more source