Results 121 to 130 of about 679,894 (427)

Wogonin Attenuates Atherosclerosis via KLF11‐Mediated Suppression of PPARα‐YAP1‐Driven Glycolysis and Enhancement of ABCA1/G1‐Mediated Cholesterol Efflux

Advanced Science, EarlyView.
PPARα promotes KLF11 expression and recruits KLF11 and YAP1 to form a transcription complex, where KLF11 acts as a brake in PPARα‐YAP1‐mediated glycolysis. Wogonin reshapes the metabolism of macrophages from glycolysis to fatty acid oxidation via activation of the PPARα‐KLF11‐YAP1 pathway, by which wogonin reduces inflammation and foam cell formation ...
Chuanrui Ma, Yunqing Hua, Shu Yang, Yun Zhao, Wei Zhang, Yaodong Miao, Jing Zhang, Boxuan Feng, Guobin Zheng, Lan Li, Zhihao Liu, Han Zhang, Mingjun Zhu, Xiumei Gao, Guanwei Fan   +14 more
wiley   +1 more source

Serum Resistin Level and Progression of Atherosclerosis during Glucocorticoid Therapy for Systemic Autoimmune Diseases

Metabolites, 2016
Adipokines are important regulators of several processes, including inflammation and atherosclerosis. In patients with systemic autoimmune diseases, atherosclerosis is accelerated with higher cardiovascular morbidity and mortality.
Nahoko Tanaka, Shotaro Masuoka, Natsuko Kusunoki, Toshihiro Nanki, Shinichi Kawai   +4 more
doaj   +1 more source

Optimal Treatment of Carotid Artery Disease

Journal of the American College of Cardiology, 2008
Extracranial carotid artery disease accounts for approximately 25% of ischemic strokes. Although carotid endarterectomy (CEA) is the established gold standard for carotid revascularization, carotid artery angioplasty and stenting (CAS) is continually developing into a safer and more efficacious method of stroke prevention. Embolic protection, improving
Babak S. Jahromi, Babak S. Jahromi, Robert D. Ecker, Robert D. Ecker, Elad I. Levy, Elad I. Levy, Rodney M. Samuelson, Rodney M. Samuelson, J Mocco, J Mocco, L. Nelson Hopkins, L. Nelson Hopkins   +11 more
openaire   +3 more sources

Utility of 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines in HIV-Infected Adults With Carotid Atherosclerosis. [PDF]

, 2017
BackgroundAlthough HIV is associated with increased atherosclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infected adults who may benefit from statins.
Deeks, Steven, Hsue, Priscilla, Hur, Sophia, Kalapus, SC, Li, Danny, Ma, Yifei, Phan, Binh An P, Scherzer, Rebecca, Weigel, Bernard   +8 more
core   +3 more sources

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Carotid intima-media thickness as a biomarker of subclinical atherosclerosis.

Swiss medical weekly, 2012
Intima-media thickness of the carotid artery (CIMT) and its increase is associated with several cardiovascular risk factors and manifest cardiovascular diseases. CIMT is suggested to be an important biomarker of subclinical atherosclerosis.
M. Bauer, Seraina Caviezel, A. Teynor, R. Erbel, A. Mahabadi, A. Schmidt-Trucksäss   +5 more
semanticscholar   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Mesenteric thrombosis: An unusual complication of severe acute pancreatitis—Report of two cases

Advances in Digestive Medicine, EarlyView.
Abstract The incidence of acute pancreatitis is 34 per 100 000 people in the general population and is on the rise. Approximately 15% to 20% of all patients experience severe pancreatitis, with a mortality rate nearing 20%. This condition is often linked to vascular complications, although mesenteric thrombosis is a rare presentation.
Asya Zubillaga‐Mares, Erika Barlandas‐Quintana, Aranza Judith Sánchez‐Lopez, Minnet Serrano‐Sanchez, Javier Meza‐Hernandez, Alejandra Nuñez‐Venzor   +5 more
wiley   +1 more source

GEN-O-MA project: an Italian network studying clinical course and pathogenic pathways of moyamoya disease—study protocol and preliminary results [PDF]

, 2019
Background: GENetics of mOyaMoyA (GEN-O-MA) project is a multicenter observational study implemented in Italy aimed at creating a network of centers involved in moyamoya angiopathy (MA) care and research and at collecting a large series and bio ...
Acerbi, Francesco, Baracchini, Claudio, Bedini, Gloria, Bersano, Anna, Binelli, Simona, Blecharz, Kinga, Bono, Giorgio, Bruzzone, Maria Grazia, Calloni, Maria Vittoria, Capone, Fioravanti, Capra, Valeria, Caputi, Luigi, Caria, Filomena, Carolei, Antonio, Caso, Valeria, Cenzato, Marco, Ciceri, Elisa, Ciusani, Emilio, De Lodovici, Maria Luisa, Dell' Acqua, Maria Luisa, Di Lazzaro, Vincenzo, Di Piero, Vittorio, Esposito, Silvia, Faragò, Giuseppe, Farina, Filippo, Ferroli, Paolo, Franceschetti, Silvana, Fratianni, Alessia, Gioppo, Andrea, Grisoli, Marina, Lanfranconi, Silvia, Lasserve, Elisabeth Tournier, Marzoli, Stefania Bianchi, Nardocci, Nardo, Nava, Sara, null, null, Paciaroni, Maurizio, Pantaleoni, Chiara, Pantoni, Leonardo, Parati, Eugenio Agostino, Pavanello, Marco, Perrone, Patrizia, Pezzini, Alessandro, Prontera, Paolo, Raso, Alessandro, Riva, Daria, Romani, Alfredo, Sacco, Simona, Saletti, Veronica, Sanguigni, Sandro, Sarti, Cristina, Sebastiano, Davide Rossi, Toni, Danilo, Toscano, Massimiliano, Vajkoczy, Peter, Zedde, Maria Luisa, Zibordi, Federica, Zini, Andrea   +57 more
core   +1 more source

Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy.

Clinical Infectious Diseases, 2009
BACKGROUND Human immunodeficiency virus (HIV)-infected patients are at increased risk of cardiovascular disease, which may be related to chronic inflammation and endothelial dysfunction despite virological control with antiretroviral therapy.
A. Ross, Nesrine A. Rizk, M. O'riordan, V. Dogra, Dalia El-Bejjani, Norma J. Storer, Danielle Harrill, Marisa Tungsiripat, J. Adell, G. McComsey   +9 more
semanticscholar   +1 more source