Results 311 to 320 of about 4,905,490 (375)

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

Cell Proliferation, EarlyView.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen   +9 more
wiley   +1 more source

A Case of Bilateral Carotid Body Tumors Requiring Surgical Resection: The Importance of Physical Exams. [PDF]

Cureus
Balakrishnan P, Adkins T, Krantz M, Kitchen JC.   +3 more
europepmc   +1 more source

Arterial stiffness and atherosclerosis and incident cardiovascular events and all‐cause mortality in individuals with manifest cardiovascular disease with and without type 2 diabetes

Diabetic Medicine, EarlyView.
Arterial stiffness and atherosclerosis and incident cardiovascular events and all‐cause mortality in individuals with manifest cardiovascular disease with and without type 2 diabetes. Abstract Background It is unclear if arterial stiffness and atherosclerosis are differentially related to cardiovascular events and mortality in individuals with manifest
Jan F. de Leijer, Frank L. J. Visseren, Birgitta K. Velthuis, Ynte M. Ruigrok, Jaco J.M. Zwanenburg, Manon G. van der Meer, Martin Teraa, Pim A. de Jong, Thomas T. van Sloten, on behalf of the UCC‐SMART study group   +9 more
wiley   +1 more source

Hypoxic Signaling Pathways in Carotid Body Tumors. [PDF]

Cancers (Basel)
Cao K, Yuan W, Hou C, Wang Z, Yu J, Wang T.   +5 more
europepmc   +1 more source

A case report of coexisting multinodular goiter with carotid body tumor. [PDF]

Int J Surg Case Rep
Wardak AF, Ghani T, Ardam SI, Musamim MA, Ghani T, Alamy H.   +5 more
europepmc   +1 more source

Long‐term preservation of kidney function with SGLT‐2 inhibitors versus comparator drugs in people with type 2 diabetes and chronic kidney disease

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Chronic kidney disease (CKD) is a prevalent and serious complication of type 2 diabetes (T2D). This study aims to evaluate kidney outcomes in a real‐world cohort of patients with T2D and CKD who received SGLT2 inhibitors (SGLT2i) or other glucose‐lowering medications (GLM).
Gian Paolo Fadini, Enrico Longato, Mario Luca Morieri, Fabio Broglio, Gianluca Aimaretti, Giuseppina T. Russo, Roberto Anichini, Mariangela Ghiani, Angelo Avogaro, Anna Solini, DARWIN‐Renal Study Investigators, Maria Pompea Antonia Baldassarre, Gloria Formoso, Agostino Consoli, Sara Morgante, Antonella Zugaro, Marco Giorgio Baroni, Francesco Andreozzi, Adriano Gatti, Stefano De Riu, Andrea Del Buono, Raffaella Aldigeri, Riccardo Bonadonna, Alessandra Dei Cas, Angela Vazzana, Monica Antonini, Valentina Moretti, Patrizia Li Volsi, Miranda Cesare, Giorgio Zanette, Silvia Carletti, Paola D'Angelo, Gaetano Leto, Frida Leonetti, Ernesto Maddaloni, Raffaella Buzzetti, Simona Frontoni, Maria Gisella Cavallo, Ilaria Barchetta, Susanna Morano, Tiziana Filardi, Umberto Capece, Andrea Giaccari, Antonio C. Bossi, Giancarla Meregalli, Fabrizio Querci, Alessia Gaglio, Veronica Resi, Emanuela Orsi, Stefano Fazion, Ivano G. Franzetti, Cesare Berra, Silvia Manfrini, Gabriella Garrapa, Giulio Lucarelli, Lara Riccialdelli, Elena Tortato, Marco Zavattaro, Gianluca Aimaretti, Franco Cavalot, Guglielmo Beccuti, Fabio Broglio, Bruno Fattor, Giuliana Cazzetta, Olga Lamacchia, Anna Rauseo, Salvatore De Cosmo, Rosella Cau, Mariangela Ghiani, Antonino Di Benedetto, Antonino Di Pino, Salvatore Piro, Francesco Purrello, Lucia Frittitta, Agostino Milluzzo, Giuseppina Russo, Anna Solini, Monia Garofolo, Giuseppe Penno, Stefano Del Prato, Roberto Anichini, Gian Paolo Fadini, Angelo Avogaro, Mauro Rigato, Agostino Paccagnella, Marco Strazzabosco, Massimo Cigolini, Enzo Bonora   +87 more
wiley   +1 more source

Carotid body dysregulation contributes to Long COVID symptoms. [PDF]

Commun Med (Lond)
El-Medany A, Adams ZH, Blythe HC, Hope KA, Kendrick AH, Abdala Sheikh AP, Abdala Sheikh AP, Paton JFR, Nightingale AK, Hart EC.   +9 more
europepmc   +1 more source

Bosutinib mitigates inflammation in experimental sepsis

European Journal of Clinical Investigation, EarlyView.
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha, V. H. P. Abreu, V. Estato, G. M. V. Soares, B. P. T. Moraes, G. P. Oliveira, J. D. Silva, P. L. Silva, R. Immler, P. R. Rocco, M. Sperandio, A. R. Silva, P. T. Bozza, H. C. Castro‐Faria‐Neto, C. F. Gonçalves‐de‐Albuquerque   +14 more
wiley   +1 more source

Reductive stress in mitochondria isolated from the carotid body of type 1 diabetic male Wistar rats. [PDF]

Physiol Rep
Tejeda-Chavez HR, Montero S, Saavedra-Molina A, Lemus M, Tejeda-Luna JB, Roces de Alvarez-Buylla E.   +5 more
europepmc   +1 more source

Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction

European Journal of Clinical Investigation, EarlyView.
In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa, Antoine Poirier, Pascale Pignon, Justine Beaumont, Lucie Lebeau, Agnès Barbelivien, Thomas Bochaton, Céline Beauvillain, Daniel Henrion, Yves Delneste, Pascale Jeannin, Fabrice Prunier, Sophie Tamareille   +12 more
wiley   +1 more source