Results 21 to 30 of about 425,158 (263)

Disruption of the RNA modifications that target the ribosome translation machinery in human cancer

Molecular Cancer, 2020
Genetic and epigenetic changes deregulate RNA and protein expression in cancer cells. In this regard, tumors exhibit an abnormal proteome in comparison to the corresponding normal tissues.
Maxime Janin, Laia Coll-SanMartin, Manel Esteller   +2 more
doaj   +1 more source

TECNOLOGÍA 5G

Revista Ingeniería, Matemáticas y Ciencias de la Información, 2017
Este documento contiene información sobre la próxima generación de tecnología de telecomunicaciones móviles que se espera que se implemente en el año 2020, más allá de las mejoras en velocidad, se espera que la tecnología 5G desplegará un «Ecosistema ...
NÉSTOR JARAMILLO, ALEXANDER OCHOA, WILLIAM PÁEZ, ALEXANDER PEÑA   +3 more
doaj   +1 more source

Willingness to Pay for Community Health Fund Card in Mtwara Rural District,Tanzania [PDF]

, 2003
\ud The Ministry of Health in Tanzania has established a new programme in the primary health care service. CHF is a district-level prepayment scheme targeted at the rural population.CHF starts in 1995 on a pilot basis in one district and in 2003 has to ...
Baraldes, Carme, Carreras , Lluis
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Participantes en eventos populares de ciclismo de montaña en áreas protegidas periurbanas: ¿dónde está el límite?

Apunts: Educación Física y Deportes
En los entornos periurbanos, los eventos deportivos al aire libre, como el ciclismo o las carreras de montaña, suelen llevarse a cabo en espacios naturales y protegidos.
Ricardo Manuel Nogueira Mendes, Carlos Pereira da Silva, Estela Inés Farías-Torbidoni, Teresa Santos   +3 more
doaj   +1 more source

AUV/ASC cooperative survey [PDF]

, 2016
In this paper we describe a solution to perform autonomous surveys taking advantage of a cooperative multivehicle setup. In the proposed configuration, an ASC provides –through an USBL- absolute positioning and communications to an AUV.
Carreras, Marc, Hurtós, Natalia, Palomeras, Narcís   +2 more
core  

Genome‐Wide DNA Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Giant cell arteritis (GCA) is a large‐vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in the arterial tissue of patients with this vasculitis. Methods DNA methylation profiling was analyzed in 79
Gonzalo Borrego‐Yaniz, Ana Márquez, Elkyn Estupiñán‐Moreno, Laura C. Terrón‐Camero, Miguel A. González‐Gay, Santos Castañeda, Giuliana Guggino, David Saadoun, Pietro Lio, Simona Fontana, Martina Bonacini, Alessandro Rossi, Alberto Cavazza, Francesco Muratore, Carlo Salvarani, Nicolo Pipitone, Javier Martin, Stefania Croci, Lourdes Ortiz‐Fernández   +18 more
wiley   +1 more source

Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18

Scientific Reports, 2021
Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations.
Michael Maher, Jeannine Diesch, Marguerite-Marie Le Pannérer, Marta Cabezón, Mar Mallo, Sara Vergara, Aleix Méndez López, Alba Mesa Tudel, Francesc Solé, Marc Sorigue, Lurdes Zamora, Isabel Granada, Marcus Buschbeck   +12 more
doaj   +1 more source

Treatment of a large cohort of childhood chronic non‐infectious uveitis a multicentric large study: adalimumab versus methotrexate as first line therapy

Arthritis &Rheumatology, Accepted Article.
Background Treatment of childhood chronic idiopathic uveitis (cCIU) is predominantly based on studies in Juvenile Idiopathic Arthritis associated uveitis and expert opinion. Our aim was to report the treatment outcomes of our cohort of cCIU. Methods Retrospective multicenter study involving the rheuma/ophthalmology units at Florence and Bristol.
Ilaria Maccora, Catherine Guly, Cinzia de Libero, Giulia Carreras, Athimalaipet V. Ramanan, Gabriele Simonini   +5 more
wiley   +1 more source

Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope

Journal for ImmunoTherapy of Cancer, 2020
Background There are few therapeutic options available for patients with B-cell acute lymphoblastic leukemia (B-ALL) relapsing as CD19– either after chemotherapy or CD19-targeted immunotherapies.
Pablo Menendez, Pablo Engel, Clara Bueno, Matteo Libero Baroni, Talia Velasco-Hernandez, Heleia Roca-Ho, Francisco Gutierrez-Aguera, Paolo Petazzi, Diego Sánchez-Martínez, Oscar Molina, Paola Ballerini, Narcis Fernandez-Fuentes   +11 more
doaj   +1 more source