Results 201 to 210 of about 109,317 (307)

Nasal colonization, risk factors, and antibiotic resistance of methicillin-resistant <i>Staphylococcus aureus</i> in Gabonese hospitals. [PDF]

Front Microbiol
Gondi Nzamba BF, Ngoubangoye B, Otsaghe Ekore D, Dikoumba AC, Nzue Nguema J, Ntsaga Matamba EC, Okomo Nguema Y, Dibakou SE, Matangoye W, Pontier D.   +9 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Prevalence of <i>pfdhfr-pfdhps</i> Sextuple and Gametocyte-Associated Quintuple Sulfadoxine-Pyrimethamine Resistance Mutations in <i>Plasmodium falciparum</i> Isolates from Pregnant Women in Mozambique. [PDF]

Pathogens
Drissi-El Boukili Y, Rovira-Vallbona E, Guetens P, Chiheb D, Kattenberg JH, Kestens L, Enosse SMM, Rosanas-Urgell A, Arnaldo P.   +8 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Colibactin (<i>pks</i>) carriage in <i>Escherichia coli</i> is associated with lineage restriction, reduced plasmid burden, and lower antimicrobial resistance. [PDF]

Front Microbiol
Azour A, Matar GM, Bilen M.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Molecular epidemiological analysis of <i>Vibrio parahaemolyticus</i> in foodborne diseases in Liaoning province, 2023-2024. [PDF]

Front Public Health
Wang W, Liu X, Yu L, Zhang M, Wei T, Li X, Ma J, Zhao T, Zheng Y, Wang Q, Wang Y, Diao W.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Meningococcal carriage and transmission dynamics in college students in Louisville, Kentucky. [PDF]

PLoS One
Arnold FW, Parrish LW, Marimuthu S, Findlow J, Quinn A, Salunkhe V, Sheikh D, Bressoud P, Ali T, Balcom D, Ali M, Doster RS, Deepti D, Tahboub M, Ndiaye F, Lucidarme J, Clark SA, Borrow R, Balmer P, Gootee S, CERID study group.   +20 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source