Results 241 to 250 of about 109,317 (307)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Pooled analysis of PCV13 efficacy from controlled human infection trials in Malawi and the UK. [PDF]

NPJ Vaccines
Kudowa E, Tembo G, Chirwa AE, Chikaonda T, Muyaya A, Makhaza L, Nsomba E, Galafa B, Thole F, Ndaferankhande J, Chimgoneko L, Toto N, Dula D, Morton B, Pennington SH, Hyder-Wright A, Collins AM, Mitsi E, Ferreira DM, Gordon SB, Henrion MYR, MARVELS, EHPC consortia.   +22 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Distribution of <i>Streptococcus pneumoniae</i> Serotypes in Nasopharyngeal Carriage Among Children in Indonesia and Estimated Coverage of Pneumococcal Conjugate Vaccines: A Systematic Review. [PDF]

Vaccines (Basel)
Prayitno A, Karyanti MR, Putri ND, Wicaksana P, Felicia F, Ninditya S, Kemalasari S, Ardine A, Satari HI, Hadinegoro SR.   +9 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Impact of a multimodal hand hygiene intervention on methicillin-resistant Staphylococcus aureus carriage among healthcare workers in Libya: a quasi-experimental pre-post study. [PDF]

Antimicrob Resist Infect Control
Alwashaish MM.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Population genomic variation in <i>Staphylococcus aureus</i> isolates from carriage and disease in Indigenous communities in the Southwest United States. [PDF]

Microb Genom
Cella E, Sutcliffe CG, Yazzie D, Anderson AS, Andrew L, Becenti L, Brasinikas G, Christensen L, Cowboy W, Dixon SL, Grant LR, Hao L, Hubler R, Jones H, Montanez P, Parker D, Rajyaguru U, Rice A, Romancito E, Salabye C, Tenequer VL, Thompson P, Tsingine M, Tso C, VanDeRiet D, Hammitt LL, Azarian T.   +26 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK. [PDF]

Microb Genom
Wilson HJ, Polgarova P, Khokhar FA, Warne B, Carpenter R, Blane B, Enoch DA, Brown NM, Preller J, Summers C, Peacock SJ, Dougan G, Parkhill J, Thomson NR, Török ME.   +14 more
europepmc   +1 more source