Results 191 to 200 of about 1,197,586 (303)

A Prospective, Multi-Site Study of Performance of Cell-Free DNA Testing for Recessive Conditions in a Large, General-Risk Pregnancy Population. [PDF]

Obstet Gynecol
McElwee ER, Wynn J, Rego S, Haddad A, Levan R, Hoskovec J, Crowe R, Robinson J, Payne J, Shondel S, Byrnes J, Hill K, Wiggins-Smith J, Faletti LC, Tims S, Helton K, Hall A, Alvarez Perez J, Haddad AS, Verma S, Hardisty EE, Czerwinski JL, Ashimi SS, Vora NL, Subramaniam A.   +24 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Smart colorectal endoscopic submucosal dissection: integrating traction, pocket creation and underwater dissection to enhance efficiency. [PDF]

Endoscopy
Gaulin PA, Carrier P, Geyl S, Albouys J, Legros R, Pioche M, Jacques J.   +6 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Influence of community disadvantage on cognitive performance in son-mother dyads in Duchenne muscular dystrophy. [PDF]

Brain Commun
Karra H, Penumalee VS, Arun S, Javalkar S, Bibat G, Ridder M, Kaat AJ, Thangarajh M.   +7 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Efficient Hot Carrier Management in Lead Halide Perovskite Micro-Disks Revealed by Super-Diffusive Migration. [PDF]

Adv Sci (Weinh)
Pathoor N, Omagari S, Vacha M.
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Effects of Vacuum Freeze-Drying and Spray-Drying Coupled with Maltodextrin and <i>β</i>-Cyclodextrin on Cactus (<i>Opuntia ficus</i>-<i>indica</i>) Postbiotic Powders. [PDF]

Foods
Ren Y, Ren S, Li J, Cui W, Xu Y, Hua G, Li C, Lyu Y, Xue H.   +8 more
europepmc   +1 more source