Results 301 to 310 of about 7,114,272 (394)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes. [PDF]

Nat Prod Rep, 2018
Gulick AM, Aldrich CC.
europepmc   +1 more source

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins

, 2016
Matthew Jenner, José P. Afonso, Christoph Kohlhaas, Petra Karbaum, Sarah Frank, Jörn Piel, Neil J. Oldham   +6 more
openalex   +2 more sources

Acyl Carrier Protein

Journal of Biological Chemistry, 1968
J Elovson, P R Vagelos
openaire   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Resolution of distinct steps in mitochondrial protein import [PDF]

, 1988
Bradshaw, Ralph A., Douglas, M. G., Hartl, Franz-Ulrich, McAlister-Henn, L., Neupert, Walter, Pfanner, Nikolaus   +5 more
core  

Subclinical echocardiographic abnormalities in phenotype-negative carriers of myosin-binding protein C3 gene mutation for hypertrophic cardiomyopathy

, 2011
Sabe De, Allen G. Borowski, Heng Wang, Leah Nye, Baozhong Xin, James D. Thomas, W.H. Wilson Tang   +6 more
openalex   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay. [PDF]

ACS Chem Biol, 2018
Hashimoto M, Girardi E, Eichner R, Superti-Furga G.   +3 more
europepmc   +1 more source

Selftrapping, biomolecules and free electron lasers [PDF]

, 2003
A Marshall Stoneham, Achterhold K, Alexander D M, Austin R H, Barker A S, D'Ovidio F, Davydov A S, Davydov A S, Housely R M, Itoh N, Johnson D P, Landau L D, Per-Anker Lindg rd, Shluger A L, Shluger A L, Steiner M J, Stoneham A M, Stoneham A M, Su W P, Wallace D S, Xie A, Zaccai G   +21 more
core   +1 more source