Results 51 to 60 of about 12,723,087 (291)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Asymetrix Currency Turbulence with US Dollar/Japanese Yen Carry Trade: Insights into Central Bank Interventions and Exchange-Rate Dynamics [PDF]

open access: yesFinancial Markets, Institutions and Risks
This study investigates the time-varying effectiveness of central bank interventions in the USDJPY exchange rate market, focusing on their asymmetric impacts under varying market conditions.
Masaaki Yoshimori
doaj   +1 more source

Carry Trade vs. Deposit-Driven Euroization

open access: yesSocial Science Research Network, 2018
Financial “euroization”—or “dollarization” outside of Central and Eastern Europe—is typically analyzed as a singular phenomenon that can be traced to a common set of factors. This paper argues that two types of euroization need to be distinguished, which
Nan Geng   +2 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

United States amphibian imports pose a disease risk to salamanders despite Lacey Act regulations

open access: yesCommunications Earth & Environment, 2023
Batrachochytrium salamandrivorans (Bsal), one of two fungal pathogens that cause the deadly amphibian disease chytridiomycosis, is a major impending threat to salamander biodiversity in North America, where it is not yet known to occur.
Patrick J. Connelly   +3 more
doaj   +1 more source

A tool for rapid assessment of wildlife markets in the Asia-Pacific Region for risk of future zoonotic disease outbreaks

open access: yesOne Health, 2021
Decades of warnings that the trade and consumption of wildlife could result in serious zoonotic pandemics have gone largely unheeded. Now the world is ravaged by COVID-19, with tremendous loss of life, economic and societal disruption, and dire ...
Eric Wikramanayake   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

open access: yesFEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto   +6 more
wiley   +1 more source

Weaknesses of Strong Ruble

open access: yesМир новой экономики, 2018
The article describes the macroeconomic consequences of the overvalued ruble policy (1996-2010s). It explains the impact of carry trade on financial crises in 1998, 2008-2009, 2014. The five scenarios of future financial crises are discussing.
Y. M. Mirkin, I. V. Dobashina
doaj  

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