Results 101 to 110 of about 921,908 (302)

Starting a Private Foundation: Carrying Out the Donor's Intent

open access: yes, 1999
A beginners guide to setting up a private foundation, this report is designed to provide the reader with a general insight into the world of philanthropy and specific observations about private foundations.
Stephanie H. Denby, Paul K. Rhoads
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Effect on carrying out cognitive behavior therapy for schizophrenia patients

open access: yesHuli yanjiu, 2005
Objective:Probe into the effect of cognitive behavior therapy to treat patients with schizophrenia.Method:Atotal of 62 schizophrenia patients met to diagnostic standards of CCMD-2-R,of whom had negative symptommainly eredivided in todrugtreatmentgroup ...
韩静, 吕静芹, 王以云, 孙红
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Probe into carrying out socialized standardized management for accompanying groups

open access: yesHuli yanjiu, 2004
[目的 ]探讨医院在护理人员缺编的情况下 ,对陪护人员实行社会化规范管理。 [方法 ]对陪护人员实行公开招聘、统一管理。上岗前进行业务培训、考核 ,签订用工协议书 ,制定奖罚条例 ,定期考核陪护人员德、勤、能、绩情况 ,随时进行督促检查 ,发现问题及时解决。 [结果 ]实施陪护人员社会化规范管理以来 ,陪护率下降 ,受到护理人员、病人及病人家属的一致好评。 [结论 ]陪护人员社会化规范管理可有效提高病房护理管理质量 ,使医院获得社会效益和经济效益的双赢。
罗雪琴, 罗小燕
doaj  

Home - About - Disclaimer - Privacy